biostudies-literatureVohr BRNICHD NIH HHSNCATS NIH HHSNCRR NIH HHSe905-14https://www.ebi.ac.uk/biostudies/studies/S-EPMC3784290biostudies-literatureUnknown132(4)To evaluate the association between severity of cerebral palsy (CP) and growth to 6 to 7 years of age among children with moderate to severe (Mod/Sev) hypoxic ischemic encephalopathy (HIE). It was hypothesized that children with Mod/Sev CP would have poorer growth, lower cognitive scores, and increased rehospitalization rates compared with children with no CP (No CP).Among 115 of 122 surviving children followed in the hypothermia trial for neonatal HIE, growth parameters and neurodevelopmental status at 18 to 22 months and 6 to 7 years were available. Group comparisons (Mod/Sev CP and No CP) with unadjusted and adjusted analyses for growth <10th percentile and z scores by using Fisher's exact tests and regression modeling were conducted.Children with Mod/Sev CP had high rates of slow growth and cognitive and motor impairment and rehospitalizations at 18 to 22 months and 6 to 7 years. At 6 to 7 years of age, children with Mod/Sev CP had increased rates of growth parameters <10th percentile compared with those with No CP (weight, 57% vs 3%; height, 70% vs 2%; and head circumference, 82% vs 13%; P < .0001). Increasing severity of slow growth was associated with increasing age (P < .04 for weight, P < .001 for length, and P < .0001 for head circumference). Gastrostomy feeds were associated with better growth.Term children with HIE who develop Mod/Sev CP have high and increasing rates of growth <10th percentile by 6 to 7 years of age. These findings support the need for close medical and nutrition management of children with HIE who develop CP.PediatricsCerebral palsy and growth failure at 6 to 7 years.PMC3784290U10 HD036790U10 HD040492U10 HD027904U10 HD040461M01 RR80UL1 TR000439U10 HD27904U10 HD034216U10 HD027871M01 RR016587U10 HD027851U10HD21364UL1 RR024139M01 RR008084U10 HD027880U10 HD027856U10 HD021385U10 HD021373U10 HD021364U10 HD021397U10 HD040521U10 HD027853U10 HD040689Foy KANelson KGAllison MAlaniz NISiner BSGrisby CGrimes SFanaroff AAWilliams JMichaelCotten CPoole WMcDavid GEEvans PWKaegi DMorgan JSNoel LSmith LLHerron DEZaterka-Baxter KMRichard LSchibler KGoldstein RFVaucher YETorres LEDieterich SCunningham MCalejo MStephens BEMadison SJiminez MAmbalavanan NHeyne RJJain LDuara SWalsh MCTyson JEMiller LCGoldberg RNPoundstone MPappas AWatson VECedillo MLaptook ARBauer CRHenderson CPhelps DLBoatman CBass NDeLancy SVohr BREhrenkranz RAFrade Eguaras SMAkpa EGSteichen JJGuzman ASchaefer SEWilson LDHale ECBridges KFuller MGCollins MVJobe AHBissey JArnell KSiddiki SPoulsen JCosby SSSalhab WAMcClure EMGreen CMiller NAHuitema CMBlackwelder AMFiner NNHust DYolton KCaplan MSPeralta- Carcelen MWhitely LLNewman JEWilson-Costello DEFriedman HGCarlton DPKonstantino MGauthier SPruitt PJSanchez PJHensley GFisher KAJohnson YRHensman AMMincey HLCarlo WALemons JAAuten KJHastings BKExtended Hypothermia Follow-up Subcommittee of the NICHD Neonatal Research NetworkWright SLMajor-Kincade TGustafson KEGettner PHessling JHammond JKennedy DLis AEBall MVan Meurs KPRomano EBara RSimmons MCDooley CMcDonald SALohmeyer MBFranco CIReddoch SHiriart-Fajardo SShankaran SReubens LJStevenson DKDonovan EFGuillet RHiggins RDMyers GJFritz SLeps MHPierce Tate PLRich WGoldston LAAlexander BOh WHickman JFGratton TLMuran GBroyles REverett-Thomas RArcher SWAuman JODeAnda MEKennedy KANewman NSRasmussen MRMorris BHPoindexter BBDas ALeach TMPhillips VAWright LLAppel DDRosenfeld CRHintz SRfalseCerebral palsy and growth failure at 6 to 7 years.To evaluate the association between severity of cerebral palsy (CP) and growth to 6 to 7 years of age among children with moderate to severe (Mod/Sev) hypoxic ischemic encephalopathy (HIE). It was hypothesized that children with Mod/Sev CP would have poorer growth, lower cognitive scores, and increased rehospitalization rates compared with children with no CP (No CP).Among 115 of 122 surviving children followed in the hypothermia trial for neonatal HIE, growth parameters and neurodevelopmental status at 18 to 22 months and 6 to 7 years were available. Group comparisons (Mod/Sev CP and No CP) with unadjusted and adjusted analyses for growth <10th percentile and z scores by using Fisher's exact tests and regression modeling were conducted.Children with Mod/Sev CP had high rates of slow growth and cognitive and motor impairment and rehospitalizations at 18 to 22 months and 6 to 7 years. At 6 to 7 years of age, children with Mod/Sev CP had increased rates of growth parameters <10th percentile compared with those with No CP (weight, 57% vs 3%; height, 70% vs 2%; and head circumference, 82% vs 13%; P < .0001). Increasing severity of slow growth was associated with increasing age (P < .04 for weight, P < .001 for length, and P < .0001 for head circumference). Gastrostomy feeds were associated with better growth.Term children with HIE who develop Mod/Sev CP have high and increasing rates of growth <10th percentile by 6 to 7 years of age. These findings support the need for close medical and nutrition management of children with HIE who develop CP.2013-01-01T00:00:00Z2013 Oct2021-02-20T04:08:49Z2019-03-27T01:16:32ZS-EPMC37842902401941510.1542/peds.2012-3915