biostudies-literatureXu JNCRR NIH HHSNHLBI NIH HHS646-50https://www.ebi.ac.uk/biostudies/studies/S-EPMC379200biostudies-literatureUnknown71(3)Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits.American journal of human geneticsMajor recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12.PMC379200R01 HL066393R01-HL48341R01-HL66393P41 RR003655R01 HL0483411-P41-RR03655Bleecker ERJongepier HKoppelman GHMeyers DAPostma DSHoward TDXu JfalseMajor recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12.Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits.2002-01-01T00:00:00Z2002 Sep2024-11-06T14:42:17.635Z2019-06-05T19:23:03ZS-EPMC3792001211960210.1086/342216