{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bazan JF"],"funding":["NICHD NIH HHS","NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["225-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3794667"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(3)"],"pubmed_abstract":["We report that the metazoan Wnt protease and signaling inhibitor TIKI shares sequence homology with bacterial TraB/PrgY proteins, inhibitors of pheromone signaling essential for propagation of antibiotic resistance. Our analysis suggests that these proteins represent an ancient metalloprotease clan regulating cellular communications across biological kingdoms."],"journal":["Developmental cell"],"pubmed_title":["The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?"],"pmcid":["PMC3794667"],"funding_grant_id":["R01 AR060359","P30 HD018655","P30 HD-18655","GM057603S1","R01 GM057603"],"pubmed_authors":["Macdonald BT","Bazan JF","He X"],"additional_accession":[]},"is_claimable":false,"name":"The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?","description":"We report that the metazoan Wnt protease and signaling inhibitor TIKI shares sequence homology with bacterial TraB/PrgY proteins, inhibitors of pheromone signaling essential for propagation of antibiotic resistance. Our analysis suggests that these proteins represent an ancient metalloprotease clan regulating cellular communications across biological kingdoms.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 May","modification":"2026-05-02T08:46:33.706Z","creation":"2019-03-27T01:17:04Z"},"accession":"S-EPMC3794667","cross_references":{"pubmed":["23673329"],"doi":["10.1016/j.devcel.2013.04.019"]}}