biostudies-literatureBazan JFNICHD NIH HHSNIAMS NIH HHSNIGMS NIH HHS225-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC3794667biostudies-literatureUnknown25(3)We report that the metazoan Wnt protease and signaling inhibitor TIKI shares sequence homology with bacterial TraB/PrgY proteins, inhibitors of pheromone signaling essential for propagation of antibiotic resistance. Our analysis suggests that these proteins represent an ancient metalloprotease clan regulating cellular communications across biological kingdoms.Developmental cellThe TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?PMC3794667R01 AR060359P30 HD018655P30 HD-18655GM057603S1R01 GM057603Macdonald BTBazan JFHe XfalseThe TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?We report that the metazoan Wnt protease and signaling inhibitor TIKI shares sequence homology with bacterial TraB/PrgY proteins, inhibitors of pheromone signaling essential for propagation of antibiotic resistance. Our analysis suggests that these proteins represent an ancient metalloprotease clan regulating cellular communications across biological kingdoms.2013-01-01T00:00:00Z2013 May2026-05-02T08:46:33.706Z2019-03-27T01:17:04ZS-EPMC37946672367332910.1016/j.devcel.2013.04.019