{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["109(8)"],"submitter":["Warneke VS"],"pubmed_abstract":["<h4>Background</h4>We investigated the expression of members of the epithelial cell adhesion molecule (EpCAM) signalling pathway in gastric cancer (GC) testing the following hypotheses: are these molecules expressed in GC and are they putatively involved in GC biology.<h4>Methods</h4>The study cohort consisted of 482 patients. The following members of the EpCAM signalling pathway were analysed by immunohistochemistry and were correlated with various clinico-pathological patient characteristics: extracellular domain of EpCAM (EpEX), intracellular domain of EpCAM (EpICD), E-cadherin, β-catenin, presenilin-2 (PSEN2), and ADAM17.<h4>Results</h4>All members of the EpCAM signalling pathway were differentially expressed in GC. The expression correlated significantly with tumour type (EpEX, EpICD,"],"journal":["British journal of cancer"],"pagination":["2217-27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3798952"],"repository":["biostudies-literature"],"pubmed_title":["Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis."],"pmcid":["PMC3798952"],"pubmed_authors":["Ebert MP","Behrens HM","Warneke VS","Rocken C","Haag J","Kruger S","Simon E","Mathiak M"],"additional_accession":[]},"is_claimable":false,"name":"Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis.","description":"<h4>Background</h4>We investigated the expression of members of the epithelial cell adhesion molecule (EpCAM) signalling pathway in gastric cancer (GC) testing the following hypotheses: are these molecules expressed in GC and are they putatively involved in GC biology.<h4>Methods</h4>The study cohort consisted of 482 patients. The following members of the EpCAM signalling pathway were analysed by immunohistochemistry and were correlated with various clinico-pathological patient characteristics: extracellular domain of EpCAM (EpEX), intracellular domain of EpCAM (EpICD), E-cadherin, β-catenin, presenilin-2 (PSEN2), and ADAM17.<h4>Results</h4>All members of the EpCAM signalling pathway were differentially expressed in GC. The expression correlated significantly with tumour type (EpEX, EpICD,","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Oct","modification":"2025-04-04T19:30:08.392Z","creation":"2019-03-27T01:17:16Z"},"accession":"S-EPMC3798952","cross_references":{"pubmed":["24008668"],"doi":["10.1038/bjc.2013.536"]}}