biostudies-literatureUnknown109(8)Warneke VS<h4>Background</h4>We investigated the expression of members of the epithelial cell adhesion molecule (EpCAM) signalling pathway in gastric cancer (GC) testing the following hypotheses: are these molecules expressed in GC and are they putatively involved in GC biology.<h4>Methods</h4>The study cohort consisted of 482 patients. The following members of the EpCAM signalling pathway were analysed by immunohistochemistry and were correlated with various clinico-pathological patient characteristics: extracellular domain of EpCAM (EpEX), intracellular domain of EpCAM (EpICD), E-cadherin, β-catenin, presenilin-2 (PSEN2), and ADAM17.<h4>Results</h4>All members of the EpCAM signalling pathway were differentially expressed in GC. The expression correlated significantly with tumour type (EpEX, EpICD,British journal of cancer2217-27https://www.ebi.ac.uk/biostudies/studies/S-EPMC3798952biostudies-literatureMembers of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis.PMC3798952Ebert MPBehrens HMWarneke VSRocken CHaag JKruger SSimon EMathiak MfalseMembers of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis.<h4>Background</h4>We investigated the expression of members of the epithelial cell adhesion molecule (EpCAM) signalling pathway in gastric cancer (GC) testing the following hypotheses: are these molecules expressed in GC and are they putatively involved in GC biology.<h4>Methods</h4>The study cohort consisted of 482 patients. The following members of the EpCAM signalling pathway were analysed by immunohistochemistry and were correlated with various clinico-pathological patient characteristics: extracellular domain of EpCAM (EpEX), intracellular domain of EpCAM (EpICD), E-cadherin, β-catenin, presenilin-2 (PSEN2), and ADAM17.<h4>Results</h4>All members of the EpCAM signalling pathway were differentially expressed in GC. The expression correlated significantly with tumour type (EpEX, EpICD,2013-01-01T00:00:00Z2013 Oct2025-04-04T19:30:08.392Z2019-03-27T01:17:16ZS-EPMC37989522400866810.1038/bjc.2013.536