{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bandar JS"],"funding":["NIGMS NIH HHS"],"pagination":["11799-802"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3804837"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["135(32)"],"pubmed_abstract":["Cyclopropenimine 1 is shown to catalyze Mannich reactions between glycine imines and N-Boc-aldimines with high levels of enantio- and diastereocontrol. The reactivity of 1 is shown to be substantially greater than that of a widely used thiourea cinchona alkaloid-derived catalyst. A variety of aryl and aliphatic N-Boc-aldimines are effective substrates for this transformation. A preparative-scale reaction to deliver >90 mmol of product is shown using 1 mol % catalyst. The products of this transformation can be converted into several useful derivatives."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Cyclopropenimine-catalyzed enantioselective Mannich reactions of tert-butyl glycinates with N-Boc-imines."],"pmcid":["PMC3804837"],"funding_grant_id":["R01 GM102611"],"pubmed_authors":["Bandar JS","Lambert TH"],"additional_accession":[]},"is_claimable":false,"name":"Cyclopropenimine-catalyzed enantioselective Mannich reactions of tert-butyl glycinates with N-Boc-imines.","description":"Cyclopropenimine 1 is shown to catalyze Mannich reactions between glycine imines and N-Boc-aldimines with high levels of enantio- and diastereocontrol. The reactivity of 1 is shown to be substantially greater than that of a widely used thiourea cinchona alkaloid-derived catalyst. A variety of aryl and aliphatic N-Boc-aldimines are effective substrates for this transformation. A preparative-scale reaction to deliver >90 mmol of product is shown using 1 mol % catalyst. The products of this transformation can be converted into several useful derivatives.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Aug","modification":"2025-04-25T23:02:49.862Z","creation":"2019-03-26T23:30:06Z"},"accession":"S-EPMC3804837","cross_references":{"pubmed":["23906087"],"doi":["10.1021/ja407277a"]}}