{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(11)"],"submitter":["Fahling M"],"pubmed_abstract":["Renal hypoxia occurs in AKI of various etiologies, but adaptation to hypoxia, mediated by hypoxia-inducible factor (HIF), is incomplete in these conditions. Preconditional HIF activation protects against renal ischemia-reperfusion injury, yet the mechanisms involved are largely unknown, and HIF-mediated renoprotection has not been examined in other causes of AKI. Here, we show that selective activation of HIF in renal tubules, through Pax8-rtTA-based inducible knockout of von Hippel-Lindau protein (VHL-KO), protects from rhabdomyolysis-induced AKI. In this model, HIF activation correlated inversely with tubular injury. Specifically, VHL deletion attenuated the increased levels of serum creatinine/urea, caspase-3 protein, and tubular necrosis induced by rhabdomyolysis in wild-type mice. Mor"],"journal":["Journal of the American Society of Nephrology : JASN"],"pagination":["1806-19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3810090"],"repository":["biostudies-literature"],"pubmed_title":["Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI."],"pmcid":["PMC3810090"],"pubmed_authors":["Mathia S","Paliege A","Peters H","Neumayer HH","Fahling M","Persson PB","Koesters R","Mrowka R","Bachmann S","Rosenberger C"],"additional_accession":[]},"is_claimable":false,"name":"Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI.","description":"Renal hypoxia occurs in AKI of various etiologies, but adaptation to hypoxia, mediated by hypoxia-inducible factor (HIF), is incomplete in these conditions. Preconditional HIF activation protects against renal ischemia-reperfusion injury, yet the mechanisms involved are largely unknown, and HIF-mediated renoprotection has not been examined in other causes of AKI. Here, we show that selective activation of HIF in renal tubules, through Pax8-rtTA-based inducible knockout of von Hippel-Lindau protein (VHL-KO), protects from rhabdomyolysis-induced AKI. In this model, HIF activation correlated inversely with tubular injury. Specifically, VHL deletion attenuated the increased levels of serum creatinine/urea, caspase-3 protein, and tubular necrosis induced by rhabdomyolysis in wild-type mice. Mor","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Nov","modification":"2026-05-04T19:33:51.298Z","creation":"2026-04-07T20:55:04.516Z"},"accession":"S-EPMC3810090","cross_references":{"pubmed":["23970125"],"doi":["10.1681/ASN.2013030281","10.1681/asn.2013030281"]}}