biostudies-literatureUnknown2Hashimoto MProtooncogene T-cell leukemia 1 (TCL1), which is implicated in human T-cell prolymphocytic leukemia (T-PLL), interacts with Akt and enhances its kinase activity, functioning as an Akt kinase co-activator. Two major isoforms of TCL1 Protooncogenes (TCL1 and TCL1b) are present adjacent to each other on human chromosome 14q.32. In human T-PLL, both TCL1 and TCL1b are activated by chromosomal translocation. Moreover, TCL1b-transgenic mice have never been created. Therefore, it remains unclear whether TCL1b itself, independent of TCL1, exhibits oncogenicity. In co-immunoprecipitation assays, both ectopic and endogenous TCL1b interacted with Akt. In in vitro Akt kinase assays, TCL1b enhanced Akt kinase activity in dose- and time-dependent manners. Bioinformatics approaches utilizing multiregressOncogenesise70https://www.ebi.ac.uk/biostudies/studies/S-EPMC3816220biostudies-literatureProtooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo.PMC3816220Hirata NNoguchi HTanaka SSuizu FMasuzawa MEdamura TTokuyama WGotoh NHashimoto MMatsuda-Lennikov MNoguchi MfalseProtooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo.Protooncogene T-cell leukemia 1 (TCL1), which is implicated in human T-cell prolymphocytic leukemia (T-PLL), interacts with Akt and enhances its kinase activity, functioning as an Akt kinase co-activator. Two major isoforms of TCL1 Protooncogenes (TCL1 and TCL1b) are present adjacent to each other on human chromosome 14q.32. In human T-PLL, both TCL1 and TCL1b are activated by chromosomal translocation. Moreover, TCL1b-transgenic mice have never been created. Therefore, it remains unclear whether TCL1b itself, independent of TCL1, exhibits oncogenicity. In co-immunoprecipitation assays, both ectopic and endogenous TCL1b interacted with Akt. In in vitro Akt kinase assays, TCL1b enhanced Akt kinase activity in dose- and time-dependent manners. Bioinformatics approaches utilizing multiregress2013-01-01T00:00:00Z2013 Sep2025-04-22T16:31:39.939Z2019-03-27T01:18:03ZS-EPMC38162202404273410.1038/oncsis.2013.30