{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3"],"submitter":["Arguello JM"],"pubmed_abstract":["Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu(+) transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters, and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3817396"],"repository":["biostudies-literature"],"pubmed_title":["Mechanisms of copper homeostasis in bacteria."],"pmcid":["PMC3817396"],"pubmed_authors":["Padilla-Benavides T","Arguello JM","Raimunda D"],"additional_accession":[]},"is_claimable":false,"name":"Mechanisms of copper homeostasis in bacteria.","description":"Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu(+) transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters, and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-18T19:52:29.848Z","creation":"2019-03-27T03:08:03Z"},"accession":"S-EPMC3817396","cross_references":{"pubmed":["24205499"],"doi":["10.3389/fcimb.2013.00073"]}}