biostudies-literatureMolander GANCRR NIH HHSNIGMS NIH HHSPHS HHS5052-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC3820111biostudies-literatureUnknown15(19)The synthesis of β,γ-alkynyl esters and amides using air-stable potassium alkynyltrifluoroborates as nucleophilic partners in a mild Suzuki-Miyaura cross-coupling reaction has been achieved. Propargyl esters and amides were obtained in high yields using a low catalyst loading, and the substrate scope of the reaction has been significantly improved over previous methods.Organic lettersPd-catalyzed alkynylation of 2-chloroacetates and 2-chloroacetamides with potassium alkynyltrifluoroborates.PMC3820111R01 GM035249S10 RR016640R01 035249Traister KMMolander GAfalsePd-catalyzed alkynylation of 2-chloroacetates and 2-chloroacetamides with potassium alkynyltrifluoroborates.The synthesis of β,γ-alkynyl esters and amides using air-stable potassium alkynyltrifluoroborates as nucleophilic partners in a mild Suzuki-Miyaura cross-coupling reaction has been achieved. Propargyl esters and amides were obtained in high yields using a low catalyst loading, and the substrate scope of the reaction has been significantly improved over previous methods.2013-01-01T00:00:00Z2013 Oct2025-04-04T07:25:02.298Z2019-03-27T03:08:11ZS-EPMC38201112404082810.1021/ol402391z