biostudies-literatureUnknown35(6)Kuhla AAging often restricts the capacity of the immune system. Endotoxemia is characterized by an immune response initiated by a group of pattern recognition receptors including the receptor for advanced glycation end products (RAGE). The aim of this study was to clarify to which extent RAGE and its signaling pathways such as the so called mitogen-activated protein kinase (MAPK) pathways can contribute to the perpetuation of inflammation in the aging organism. We used senescence-accelerated-prone (SAMP8) and senescence-accelerated-resistant (SAMR1) mice and studied them at the age of 2 and 6 months. Livers of SAMP8 mice had significantly higher malondialdehyde concentrations and a modest reduction of glyoxalase-I expression. Consequently, the abundance of highly modified advanced glycation end pAge (Dordrecht, Netherlands)2153-63https://www.ebi.ac.uk/biostudies/studies/S-EPMC3824992biostudies-literatureSenescence-dependent impact of anti-RAGE antibody on endotoxemic liver failure.PMC3824992Kuhla AHauke MZechner DSempert KVollmar BfalseSenescence-dependent impact of anti-RAGE antibody on endotoxemic liver failure.Aging often restricts the capacity of the immune system. Endotoxemia is characterized by an immune response initiated by a group of pattern recognition receptors including the receptor for advanced glycation end products (RAGE). The aim of this study was to clarify to which extent RAGE and its signaling pathways such as the so called mitogen-activated protein kinase (MAPK) pathways can contribute to the perpetuation of inflammation in the aging organism. We used senescence-accelerated-prone (SAMP8) and senescence-accelerated-resistant (SAMR1) mice and studied them at the age of 2 and 6 months. Livers of SAMP8 mice had significantly higher malondialdehyde concentrations and a modest reduction of glyoxalase-I expression. Consequently, the abundance of highly modified advanced glycation end p2013-01-01T00:00:00Z2013 Dec2025-04-22T04:45:04.825Z2019-03-27T03:08:26ZS-EPMC38249922331936310.1007/s11357-012-9506-7