biostudies-literatureFjell CDCanadian Institutes of Health Researche79207https://www.ebi.ac.uk/biostudies/studies/S-EPMC3828333biostudies-literatureUnknown8(11)<h4>Introduction</h4>Inflammatory response during sepsis is incompletely understood due to small sample sizes and variable timing of measurements following the onset of symptoms. The vasopressin in septic shock trial (VASST) compared the addition of vasopressin to norepinephrine alone in patients with septic shock. During this study plasma was collected and 39 cytokines measured in a 363 patients at both baseline (before treatment) and 24 hours. Clinical features relating to both underlying health and the acute organ dysfunction induced by the severe infection were collected during the first 28 days of admission.<h4>Hypothesis</h4>Cluster analysis of cytokines identifies subgroups of patients at differing risk of death and organ failure.<h4>Methods</h4>Circulating cytokines and other signaPloS oneCytokines and signaling molecules predict clinical outcomes in sepsis.PMC3828333MCT 44152Thair SFjell CDBoyd JRussell JAHsu JLWalley KRfalseCytokines and signaling molecules predict clinical outcomes in sepsis.<h4>Introduction</h4>Inflammatory response during sepsis is incompletely understood due to small sample sizes and variable timing of measurements following the onset of symptoms. The vasopressin in septic shock trial (VASST) compared the addition of vasopressin to norepinephrine alone in patients with septic shock. During this study plasma was collected and 39 cytokines measured in a 363 patients at both baseline (before treatment) and 24 hours. Clinical features relating to both underlying health and the acute organ dysfunction induced by the severe infection were collected during the first 28 days of admission.<h4>Hypothesis</h4>Cluster analysis of cytokines identifies subgroups of patients at differing risk of death and organ failure.<h4>Methods</h4>Circulating cytokines and other signa2013-01-01T00:00:00Z20132025-04-05T14:22:28.033Z2019-03-26T23:16:57ZS-EPMC38283332424444910.1371/journal.pone.0079207