{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma Y"],"funding":["Cancer Research UK","Worldwide Cancer Research","Medical Research Council"],"pagination":["1187-91"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3828765"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(11)"],"pubmed_abstract":["The actin bundling protein fascin 1 is not expressed in adult epithelial tissues, but during development it is transiently expressed in many different cell types, and later in adults it is expressed in a subset of immune cells, nervous tissues, endothelial cells, smooth muscle cells and pericytes. In contrast to the wealth of knowledge about the role of fascin 1 in cancer cell migration and invasion, little is known about the involvement of fascin 1 in angiogenesis. We speculated that as angiogenesis involves migration and invasion of tissues by endothelial cells, fascin 1 might have a role in both normal and tumour angiogenesis. Here, we provide evidence that loss of fascin 1 causes relatively minor reductions to angiogenesis during embryonic, postnatal and cancerous development by examin"],"journal":["Biology open"],"pubmed_title":["Fascin 1 is dispensable for developmental and tumour angiogenesis."],"pmcid":["PMC3828765"],"funding_grant_id":["G0901609","15673","12-1068","12007"],"pubmed_authors":["Machesky LM","Yamashiro S","Hodivala-Dilke KM","Ma Y","Stevenson RP","Li A","Reynolds LE"],"additional_accession":[]},"is_claimable":false,"name":"Fascin 1 is dispensable for developmental and tumour angiogenesis.","description":"The actin bundling protein fascin 1 is not expressed in adult epithelial tissues, but during development it is transiently expressed in many different cell types, and later in adults it is expressed in a subset of immune cells, nervous tissues, endothelial cells, smooth muscle cells and pericytes. In contrast to the wealth of knowledge about the role of fascin 1 in cancer cell migration and invasion, little is known about the involvement of fascin 1 in angiogenesis. We speculated that as angiogenesis involves migration and invasion of tissues by endothelial cells, fascin 1 might have a role in both normal and tumour angiogenesis. Here, we provide evidence that loss of fascin 1 causes relatively minor reductions to angiogenesis during embryonic, postnatal and cancerous development by examin","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-05T14:23:20.135Z","creation":"2019-03-27T03:08:37Z"},"accession":"S-EPMC3828765","cross_references":{"pubmed":["24244855"],"doi":["10.1242/bio.20136031"]}}