biostudies-literatureMa YCancer Research UKWorldwide Cancer ResearchMedical Research Council1187-91https://www.ebi.ac.uk/biostudies/studies/S-EPMC3828765biostudies-literatureUnknown2(11)The actin bundling protein fascin 1 is not expressed in adult epithelial tissues, but during development it is transiently expressed in many different cell types, and later in adults it is expressed in a subset of immune cells, nervous tissues, endothelial cells, smooth muscle cells and pericytes. In contrast to the wealth of knowledge about the role of fascin 1 in cancer cell migration and invasion, little is known about the involvement of fascin 1 in angiogenesis. We speculated that as angiogenesis involves migration and invasion of tissues by endothelial cells, fascin 1 might have a role in both normal and tumour angiogenesis. Here, we provide evidence that loss of fascin 1 causes relatively minor reductions to angiogenesis during embryonic, postnatal and cancerous development by examinBiology openFascin 1 is dispensable for developmental and tumour angiogenesis.PMC3828765G09016091567312-106812007Machesky LMYamashiro SHodivala-Dilke KMMa YStevenson RPLi AReynolds LEfalseFascin 1 is dispensable for developmental and tumour angiogenesis.The actin bundling protein fascin 1 is not expressed in adult epithelial tissues, but during development it is transiently expressed in many different cell types, and later in adults it is expressed in a subset of immune cells, nervous tissues, endothelial cells, smooth muscle cells and pericytes. In contrast to the wealth of knowledge about the role of fascin 1 in cancer cell migration and invasion, little is known about the involvement of fascin 1 in angiogenesis. We speculated that as angiogenesis involves migration and invasion of tissues by endothelial cells, fascin 1 might have a role in both normal and tumour angiogenesis. Here, we provide evidence that loss of fascin 1 causes relatively minor reductions to angiogenesis during embryonic, postnatal and cancerous development by examin2013-01-01T00:00:00Z20132025-04-05T14:23:20.135Z2019-03-27T03:08:37ZS-EPMC38287652424485510.1242/bio.20136031