{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["110(45)"],"submitter":["Moczulska KE"],"pubmed_abstract":["Long-lasting changes in synaptic connections induced by relevant experiences are believed to represent the physical correlate of memories. Here, we combined chronic in vivo two-photon imaging of dendritic spines with auditory-cued classical conditioning to test if the formation of a fear memory is associated with structural changes of synapses in the mouse auditory cortex. We find that paired conditioning and unpaired conditioning induce a transient increase in spine formation or spine elimination, respectively. A fraction of spines formed during paired conditioning persists and leaves a long-lasting trace in the network. Memory recall triggered by the reexposure of mice to the sound cue did not lead to changes in spine dynamics. Our findings provide a synaptic mechanism for plasticity in sound responses of auditory cortex neurons induced by auditory-cued fear conditioning; they also show that retrieval of an auditory fear memory does not lead to a recapitulation of structural plasticity in the auditory cortex as observed during initial memory consolidation."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["18315-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3831433"],"repository":["biostudies-literature"],"pubmed_title":["Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall."],"pmcid":["PMC3831433"],"pubmed_authors":["Ushakova L","Wernle T","Rumpel S","Moczulska KE","Bathellier B","Peter M","Tinter-Thiede J"],"additional_accession":[]},"is_claimable":false,"name":"Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall.","description":"Long-lasting changes in synaptic connections induced by relevant experiences are believed to represent the physical correlate of memories. Here, we combined chronic in vivo two-photon imaging of dendritic spines with auditory-cued classical conditioning to test if the formation of a fear memory is associated with structural changes of synapses in the mouse auditory cortex. We find that paired conditioning and unpaired conditioning induce a transient increase in spine formation or spine elimination, respectively. A fraction of spines formed during paired conditioning persists and leaves a long-lasting trace in the network. Memory recall triggered by the reexposure of mice to the sound cue did not lead to changes in spine dynamics. Our findings provide a synaptic mechanism for plasticity in sound responses of auditory cortex neurons induced by auditory-cued fear conditioning; they also show that retrieval of an auditory fear memory does not lead to a recapitulation of structural plasticity in the auditory cortex as observed during initial memory consolidation.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Nov","modification":"2025-04-26T08:08:48.928Z","creation":"2019-03-27T03:08:44Z"},"accession":"S-EPMC3831433","cross_references":{"pubmed":["24151334"],"doi":["10.1073/pnas.1312508110"]}}