biostudies-literatureUnknown109(10)Giessrigl B<h4>Background</h4>Breast cancer is the leading cause of cancer death in women living in the western hemisphere. Despite major advances in first-line endocrine therapy of advanced oestrogen receptor (ER)-positive breast cancer, the frequent recurrence of resistant cancer cells represents a serious obstacle to successful treatment. Understanding the mechanisms leading to acquired resistance, therefore, could pave the way to the development of second-line therapeutics. To this end, we generated an ER-positive breast cancer cell line (MCF-7) with resistance to the therapeutic anti-oestrogen fulvestrant (FUL) and studied the molecular changes involved in resistance.<h4>Methods</h4>Naive MCF-7 cells were treated with increasing FUL concentrations and the gene expression profile of the resultingBritish journal of cancer2751-62https://www.ebi.ac.uk/biostudies/studies/S-EPMC3833203biostudies-literatureFulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex.PMC3833203Giessrigl BKalipciyan MJeitler MKrieger SMader RMKrupitza GGollinger MSchmidt WMJager WBilban MfalseFulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex.<h4>Background</h4>Breast cancer is the leading cause of cancer death in women living in the western hemisphere. Despite major advances in first-line endocrine therapy of advanced oestrogen receptor (ER)-positive breast cancer, the frequent recurrence of resistant cancer cells represents a serious obstacle to successful treatment. Understanding the mechanisms leading to acquired resistance, therefore, could pave the way to the development of second-line therapeutics. To this end, we generated an ER-positive breast cancer cell line (MCF-7) with resistance to the therapeutic anti-oestrogen fulvestrant (FUL) and studied the molecular changes involved in resistance.<h4>Methods</h4>Naive MCF-7 cells were treated with increasing FUL concentrations and the gene expression profile of the resulting2013-01-01T00:00:00Z2013 Nov2025-04-26T17:40:15.319Z2019-03-27T03:08:51ZS-EPMC38332032416935810.1038/bjc.2013.583