biostudies-literatureWardak MNCI NIH HHS6553-62https://www.ebi.ac.uk/biostudies/studies/S-EPMC3833447biostudies-literatureUnknown17(20)<h4>Purpose</h4>The primary objective of this study was to investigate whether changes in 3'-deoxy-3'-[¹⁸F]fluorothymidine (¹⁸F-FLT) kinetic parameters, taken early after the start of therapy, could predict overall survival (OS) and progression-free survival (PFS) in patients with recurrent malignant glioma undergoing treatment with bevacizumab and irinotecan.<h4>Experimental design</h4>High-grade recurrent brain tumors were investigated in 18 patients (8 male and 10 female), ages 26 to 76 years. Each had 3 dynamic positron emission tomography (PET) studies as follows: at baseline and after 2 and 6 weeks from the start of treatment, ¹⁸F-FLT (2.0 MBq/kg) was injected intravenously, and dynamic PET images were acquired for 1 hour. Factor analysis generated factor images from which blood and Clinical cancer research : an official journal of the American Association for Cancer ResearchDiscriminant analysis of ¹⁸F-fluorothymidine kinetic parameters to predict survival in patients with recurrent high-grade glioma.PMC3833447P50 CA086306P50 CA086306-06Dahlbom MSatyamurthy NHuang SCSchiepers CCloughesy TChen WWardak MPhelps MECzernin JfalseDiscriminant analysis of ¹⁸F-fluorothymidine kinetic parameters to predict survival in patients with recurrent high-grade glioma.<h4>Purpose</h4>The primary objective of this study was to investigate whether changes in 3'-deoxy-3'-[¹⁸F]fluorothymidine (¹⁸F-FLT) kinetic parameters, taken early after the start of therapy, could predict overall survival (OS) and progression-free survival (PFS) in patients with recurrent malignant glioma undergoing treatment with bevacizumab and irinotecan.<h4>Experimental design</h4>High-grade recurrent brain tumors were investigated in 18 patients (8 male and 10 female), ages 26 to 76 years. Each had 3 dynamic positron emission tomography (PET) studies as follows: at baseline and after 2 and 6 weeks from the start of treatment, ¹⁸F-FLT (2.0 MBq/kg) was injected intravenously, and dynamic PET images were acquired for 1 hour. Factor analysis generated factor images from which blood and 2011-01-01T00:00:00Z2011 Oct2025-06-01T02:47:32.971Z2025-06-01T02:47:32.971ZS-EPMC38334472186876510.1158/1078-0432.ccr-10-329010.1158/1078-0432.CCR-10-3290