{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Newman TJ"],"funding":["Cancer Research UK","NCI NIH HHS","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["9705-18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3834809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(21)"],"pubmed_abstract":["During S phase, the entire genome must be precisely duplicated, with no sections of DNA left unreplicated. Here, we develop a simple mathematical model to describe the probability of replication failing due to the irreversible stalling of replication forks. We show that the probability of complete genome replication is maximized if replication origins are evenly spaced, the largest inter-origin distances are minimized, and the end-most origins are positioned close to chromosome ends. We show that origin positions in the yeast Saccharomyces cerevisiae genome conform to all three predictions thereby maximizing the probability of complete replication if replication forks stall. Origin positions in four other yeasts-Kluyveromyces lactis, Lachancea kluyveri, Lachancea waltii and Schizosaccharom"],"journal":["Nucleic acids research"],"pubmed_title":["Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts."],"pmcid":["PMC3834809"],"funding_grant_id":["WT096598","096598","C303/A7399","BB/G001596/1","097945","U54 CA143682","BB/E023754/1","14301","WT083524","096598/Z/11/Z","WT097945"],"pubmed_authors":["Nieduszynski CA","Newman TJ","Blow JJ","Mamun MA"],"additional_accession":[]},"is_claimable":false,"name":"Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts.","description":"During S phase, the entire genome must be precisely duplicated, with no sections of DNA left unreplicated. Here, we develop a simple mathematical model to describe the probability of replication failing due to the irreversible stalling of replication forks. We show that the probability of complete genome replication is maximized if replication origins are evenly spaced, the largest inter-origin distances are minimized, and the end-most origins are positioned close to chromosome ends. We show that origin positions in the yeast Saccharomyces cerevisiae genome conform to all three predictions thereby maximizing the probability of complete replication if replication forks stall. Origin positions in four other yeasts-Kluyveromyces lactis, Lachancea kluyveri, Lachancea waltii and Schizosaccharom","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Nov","modification":"2025-04-04T12:26:49.021Z","creation":"2019-03-27T03:08:57Z"},"accession":"S-EPMC3834809","cross_references":{"pubmed":["23963700"],"doi":["10.1093/nar/gkt728"]}}