biostudies-literatureNg SKBiotechnology and Biological Sciences Research Council9786-99https://www.ebi.ac.uk/biostudies/studies/S-EPMC3834823biostudies-literatureUnknown41(21)Long double-stranded RNA may undergo hyper-editing by adenosine deaminases that act on RNA (ADARs), where up to 50% of adenosine residues may be converted to inosine. However, although numerous RNAs may undergo hyper-editing, the role for inosine-containing hyper-edited double-stranded RNA in cells is poorly understood. Nevertheless, editing plays a critical role in mammalian cells, as highlighted by the analysis of ADAR-null mutants. In particular, the long form of ADAR1 (ADAR1(p150)) is essential for viability. Moreover, a number of studies have implicated ADAR1(p150) in various stress pathways. We have previously shown that ADAR1(p150) localized to cytoplasmic stress granules in HeLa cells following either oxidative or interferon-induced stress. Here, we show that the Z-DNA-binding domaNucleic acids researchProteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules.PMC3834823BB/F018347/1Ng SKScadden ADWeissbach RRonson GEfalseProteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules.Long double-stranded RNA may undergo hyper-editing by adenosine deaminases that act on RNA (ADARs), where up to 50% of adenosine residues may be converted to inosine. However, although numerous RNAs may undergo hyper-editing, the role for inosine-containing hyper-edited double-stranded RNA in cells is poorly understood. Nevertheless, editing plays a critical role in mammalian cells, as highlighted by the analysis of ADAR-null mutants. In particular, the long form of ADAR1 (ADAR1(p150)) is essential for viability. Moreover, a number of studies have implicated ADAR1(p150) in various stress pathways. We have previously shown that ADAR1(p150) localized to cytoplasmic stress granules in HeLa cells following either oxidative or interferon-induced stress. Here, we show that the Z-DNA-binding doma2013-01-01T00:00:00Z2013 Nov2025-04-04T12:26:50.782Z2019-03-27T03:08:58ZS-EPMC38348232398251310.1093/nar/gkt750