{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(21)"],"submitter":["Yamashita A"],"pubmed_abstract":["A number of meiosis-specific transcripts are selectively eliminated during the mitotic cell cycle in fission yeast. Mmi1, an RNA-binding protein, plays a crucial role in this selective elimination. Mmi1 recognizes a specific region, namely, the determinant of selective removal (DSR) on meiotic transcripts and induces nuclear exosome-mediated elimination. During meiosis, Mmi1 is sequestered by a chromosome-associated dot structure, Mei2 dot, allowing meiosis-specific transcripts to be stably expressed. Red1, a zinc-finger protein, is also known to participate in the Mmi1/DSR elimination system, although its molecular function has remained elusive. To uncover the detailed molecular mechanisms underlying the Mmi1/DSR elimination system, we sought to identify factors that interact genetically "],"journal":["Nucleic acids research"],"pagination":["9680-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3834831"],"repository":["biostudies-literature"],"pubmed_title":["A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts."],"pmcid":["PMC3834831"],"pubmed_authors":["Yamamoto M","Takayama T","Iwata R","Yamashita A"],"additional_accession":[]},"is_claimable":false,"name":"A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.","description":"A number of meiosis-specific transcripts are selectively eliminated during the mitotic cell cycle in fission yeast. Mmi1, an RNA-binding protein, plays a crucial role in this selective elimination. Mmi1 recognizes a specific region, namely, the determinant of selective removal (DSR) on meiotic transcripts and induces nuclear exosome-mediated elimination. During meiosis, Mmi1 is sequestered by a chromosome-associated dot structure, Mei2 dot, allowing meiosis-specific transcripts to be stably expressed. Red1, a zinc-finger protein, is also known to participate in the Mmi1/DSR elimination system, although its molecular function has remained elusive. To uncover the detailed molecular mechanisms underlying the Mmi1/DSR elimination system, we sought to identify factors that interact genetically ","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Nov","modification":"2025-04-04T12:26:51.967Z","creation":"2019-03-27T03:08:58Z"},"accession":"S-EPMC3834831","cross_references":{"pubmed":["23980030"],"doi":["10.1093/nar/gkt763"]}}