biostudies-literatureUnknown41(21)Yamashita AA number of meiosis-specific transcripts are selectively eliminated during the mitotic cell cycle in fission yeast. Mmi1, an RNA-binding protein, plays a crucial role in this selective elimination. Mmi1 recognizes a specific region, namely, the determinant of selective removal (DSR) on meiotic transcripts and induces nuclear exosome-mediated elimination. During meiosis, Mmi1 is sequestered by a chromosome-associated dot structure, Mei2 dot, allowing meiosis-specific transcripts to be stably expressed. Red1, a zinc-finger protein, is also known to participate in the Mmi1/DSR elimination system, although its molecular function has remained elusive. To uncover the detailed molecular mechanisms underlying the Mmi1/DSR elimination system, we sought to identify factors that interact genetically Nucleic acids research9680-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC3834831biostudies-literatureA novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.PMC3834831Yamamoto MTakayama TIwata RYamashita AfalseA novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.A number of meiosis-specific transcripts are selectively eliminated during the mitotic cell cycle in fission yeast. Mmi1, an RNA-binding protein, plays a crucial role in this selective elimination. Mmi1 recognizes a specific region, namely, the determinant of selective removal (DSR) on meiotic transcripts and induces nuclear exosome-mediated elimination. During meiosis, Mmi1 is sequestered by a chromosome-associated dot structure, Mei2 dot, allowing meiosis-specific transcripts to be stably expressed. Red1, a zinc-finger protein, is also known to participate in the Mmi1/DSR elimination system, although its molecular function has remained elusive. To uncover the detailed molecular mechanisms underlying the Mmi1/DSR elimination system, we sought to identify factors that interact genetically 2013-01-01T00:00:00Z2013 Nov2025-04-04T12:26:51.967Z2019-03-27T03:08:58ZS-EPMC38348312398003010.1093/nar/gkt763