biostudies-literatureUnknown8(11)Kelly RS<h4>Background</h4>Cadmium (Cd) and lead (Pb) are hypothesised to be risk factors for non-Hodgkin's lymphoma (NHL), a group of haematological malignancies with a suspected environmental aetiology. Within the EnviroGenoMarkers study we utilised pre-diagnostic erythrocyte concentrations of Cd and Pb to determine whether exposure was associated with risk of B-cell NHL and multiple myeloma.<h4>Methods</h4>194 incident cases of B-cell NHL and 76 cases of multiple myeloma diagnosed between 1990 and 2006 were identified from two existing cohorts; EPIC-Italy and the Northern Sweden Health and Disease Study. Cases were matched to healthy controls by centre, age, gender and date of blood collection. Cd and Pb were measured in blood samples provided at recruitment using inductively coupled plasma-masPloS onee81892https://www.ebi.ac.uk/biostudies/studies/S-EPMC3842971biostudies-literatureBlood erythrocyte concentrations of cadmium and lead and the risk of B-cell non-Hodgkin's lymphoma and multiple myeloma: a nested case-control study.PMC3842971Kelly RSKeuna HCFazzos LBendinellim BGottschalkk RVermeulen REnviroGenoMarkersProject ConsortiumKivirantat HChadeau-Hyam MChienv KLBergdahl IAHungv HKroghn VLundh TPortengeni LJohansson ASSaberi-Hosnijehi FRantakokkot Pvan Leeuwenk DTimmermansk LGilthorpeu MVineis PAiraksinent RStephanour EGChatziioannoug AKogevinasq MHsiaov CKPapadopouloug CSacerdoteh CKleinjansk JCvanVeldhovena KJonssonb BChenv WJPalli DAthersuch TJTuu YKRuokojarvit PGeorgiadisg PMyridakisr AKyrtopoulos SAde Kokk TMPorta MCombas PBotsivali MMelinf BLeev WCValavanisg IPanicop SLennerf PFlemingu TLiaov SFFlemingu SKuov PHHallmansl GDe Santiss MTuminoo RHebelsk DGfalseBlood erythrocyte concentrations of cadmium and lead and the risk of B-cell non-Hodgkin's lymphoma and multiple myeloma: a nested case-control study.<h4>Background</h4>Cadmium (Cd) and lead (Pb) are hypothesised to be risk factors for non-Hodgkin's lymphoma (NHL), a group of haematological malignancies with a suspected environmental aetiology. Within the EnviroGenoMarkers study we utilised pre-diagnostic erythrocyte concentrations of Cd and Pb to determine whether exposure was associated with risk of B-cell NHL and multiple myeloma.<h4>Methods</h4>194 incident cases of B-cell NHL and 76 cases of multiple myeloma diagnosed between 1990 and 2006 were identified from two existing cohorts; EPIC-Italy and the Northern Sweden Health and Disease Study. Cases were matched to healthy controls by centre, age, gender and date of blood collection. Cd and Pb were measured in blood samples provided at recruitment using inductively coupled plasma-mas2013-01-01T00:00:00Z20132026-07-15T17:19:02.063Z2026-07-08T03:10:20.148ZS-EPMC38429712431237510.1371/journal.pone.0081892