biostudies-literatureBucur RCCanadian Institutes of Health Research284https://www.ebi.ac.uk/biostudies/studies/S-EPMC3847792biostudies-literatureUnknown14<h4>Background</h4>Organic nitrates uncouple bone turnover, improve bone mineral density, and improve trabecular and cortical components of bone. These changes in turnover, strength and geometry may translate into an important reduction in fractures. However, before proceeding with a large fracture trial, there is a need to identify the nitrate formulation that has both the greatest efficacy (with regards to bone turnover markers) and gives the fewest headaches. Ascertaining which nitrate formulation this may be is the purpose of the current study.<h4>Methods and design</h4>This will be an open-label randomized, controlled trial conducted at Women's College Hospital comparing five formulations of nitrates for their effects on bone turnover markers and headache. We will recruit postmenopausTrialsNitrates and bone turnover (NABT) - trial to select the best nitrate preparation: study protocol for a randomized controlled trial.PMC3847792MOP119423Jamal SAReid LSHamilton CJCummings SRBucur RCfalseNitrates and bone turnover (NABT) - trial to select the best nitrate preparation: study protocol for a randomized controlled trial.<h4>Background</h4>Organic nitrates uncouple bone turnover, improve bone mineral density, and improve trabecular and cortical components of bone. These changes in turnover, strength and geometry may translate into an important reduction in fractures. However, before proceeding with a large fracture trial, there is a need to identify the nitrate formulation that has both the greatest efficacy (with regards to bone turnover markers) and gives the fewest headaches. Ascertaining which nitrate formulation this may be is the purpose of the current study.<h4>Methods and design</h4>This will be an open-label randomized, controlled trial conducted at Women's College Hospital comparing five formulations of nitrates for their effects on bone turnover markers and headache. We will recruit postmenopaus2013-01-01T00:00:00Z2013 Sep2026-05-03T03:03:45.441Z2019-03-27T03:09:37ZS-EPMC38477922401099210.1186/1745-6215-14-284