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Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10(-10)) and clear cell (rs11651755 OR=0.77, P=1.6 × 10(-8)) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B,"],"journal":["Nature communications"],"pubmed_title":["Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer."],"pmcid":["PMC3848248"],"funding_grant_id":["P01-CA017054","R01-CA016056","R01-CA106414","13086","R01-CA149429","R01 CA054419","P50 CA105009","R01-CA080978","MSH-87734","N01-PC067001","R01-CA061132","K07-CA095666","M01-RR000056","R01-CA141154","R01 CA087696","R01-CA080742","P30 CA016056","N01 CN025403","P50 CA136393","R01-CA076016","P30 CA015083","R01-CA087538","R01-CA092044","K22-CA138563","R37-CA70867","R01-CA064277","R01-CA126841","K07 CA080668","R01-CA067262","R37-CA070867","K07-CA143047","10118","R01 CA122443","R01 CA096958","R01 CA058598","C490/A6187","R01-CA114343","U24 CA143882","R01-CA049449","R01 CA112523","R01-CA014089","P50-CA105009","R03-CA113148","R03 CA115195","N01 PC035137","P30 CA072720","C536/A13086","U01-CA069417","R01-CA050385","R01-CA074850","U01-CA071966","U19 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in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we comprehensively map variation in HNF1B with respect to epithelial ovarian cancer risk and analyse DNA methylation and expression profiles across histological subtypes. Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10(-10)) and clear cell (rs11651755 OR=0.77, P=1.6 × 10(-8)) epithelial ovarian cancer. Risk alleles for the serous subtype associate with higher HNF1B-promoter methylation in these tumours. Unmethylated, expressed HNF1B,","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2026-05-03T02:36:31.46Z","creation":"2026-04-07T18:48:35.353Z"},"accession":"S-EPMC3848248","cross_references":{"pubmed":["23535649"],"doi":["10.1038/ncomms2629"]}}