{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["70(3)"],"submitter":["Niimi T"],"pubmed_abstract":["Several traits associated with asthma phenotypes, such as high total serum immunoglobulin E and bronchial hyperresponsiveness, have been linked by numerous genome-screen studies and linkage analyses to markers on human chromosome 5q31-q34. In the present article, we describe UGRP1 (encoding uteroglobin-related protein 1) as one of asthma-susceptibility genes that is located on chromosome 5q31-q32. UGRP1 is a homodimeric secretory protein of 17 kDa and is expressed only in lung and trachea. The G --> A polymorphism was identified at -112 bp in the human UGRP1 gene promoter. The -112A allele is responsible for a 24% reduction in the promoter activity in relation to the -112G allele, as examined by transfection analysis. Electrophoretic mobility-shift analysis revealed that an unknown nuclear"],"journal":["American journal of human genetics"],"pagination":["718-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC384948"],"repository":["biostudies-literature"],"pubmed_title":["A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma."],"pmcid":["PMC384948"],"pubmed_authors":["Keck-Waggoner CL","Niimi T","Munakata M","Kimura S","Popescu NC","Levitt RC","Hisada M"],"additional_accession":[]},"is_claimable":false,"name":"A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma.","description":"Several traits associated with asthma phenotypes, such as high total serum immunoglobulin E and bronchial hyperresponsiveness, have been linked by numerous genome-screen studies and linkage analyses to markers on human chromosome 5q31-q34. In the present article, we describe UGRP1 (encoding uteroglobin-related protein 1) as one of asthma-susceptibility genes that is located on chromosome 5q31-q32. UGRP1 is a homodimeric secretory protein of 17 kDa and is expressed only in lung and trachea. The G --> A polymorphism was identified at -112 bp in the human UGRP1 gene promoter. The -112A allele is responsible for a 24% reduction in the promoter activity in relation to the -112G allele, as examined by transfection analysis. Electrophoretic mobility-shift analysis revealed that an unknown nuclear","dates":{"release":"2002-01-01T00:00:00Z","publication":"2002 Mar","modification":"2025-04-05T00:33:33.342Z","creation":"2019-03-27T00:50:19Z"},"accession":"S-EPMC384948","cross_references":{"pubmed":["11813133"],"doi":["10.1086/339272"]}}