{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Hawken S"],"pubmed_abstract":["<h4>Objective</h4>We investigated the association between a child's birth order and emergency room (ER) visits and hospital admissions following 2-,4-,6- and 12-month pediatric vaccinations.<h4>Methods</h4>We included all children born in Ontario between April 1(st), 2006 and March 31(st), 2009 who received a qualifying vaccination. We identified vaccinations, ER visits and admissions using health administrative data housed at the Institute for Clinical Evaluative Sciences. We used the self-controlled case series design to compare the relative incidence (RI) of events among 1(st)-born and later-born children using relative incidence ratios (RIR).<h4>Results</h4>For the 2-month vaccination, the RIR for 1(st)-borns versus later-born children was 1.37 (95% CI: 1.19-1.57), which translates to 112 additional events/100,000 vaccinated. For the 4-month vaccination, the RIR for 1(st)-borns vs. later-borns was 1.70 (95% CI: 1.45-1.99), representing 157 additional events/100,000 vaccinated. At 6 months, the RIR for 1(st) vs. later-borns was 1.27 (95% CI: 1.09-1.48), or 77 excess events/100,000 vaccinated. At the 12-month vaccination, the RIR was 1.11 (95% CI: 1.02-1.21), or 249 excess events/100,000 vaccinated.<h4>Conclusions</h4>Birth order is associated with increased incidence of ER visits and hospitalizations following vaccination in infancy. 1(st)-born children had significantly higher relative incidence of events compared to later-born children."],"journal":["PloS one"],"pagination":["e81070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3852020"],"repository":["biostudies-literature"],"pubmed_title":["Association between birth order and emergency room visits and acute hospital admissions following pediatric vaccination: a self-controlled study."],"pmcid":["PMC3852020"],"pubmed_authors":["Ducharme R","Kwong JC","Deeks SL","Crowcroft NS","Wilson K","Hawken S","Manuel DG"],"additional_accession":[]},"is_claimable":false,"name":"Association between birth order and emergency room visits and acute hospital admissions following pediatric vaccination: a self-controlled study.","description":"<h4>Objective</h4>We investigated the association between a child's birth order and emergency room (ER) visits and hospital admissions following 2-,4-,6- and 12-month pediatric vaccinations.<h4>Methods</h4>We included all children born in Ontario between April 1(st), 2006 and March 31(st), 2009 who received a qualifying vaccination. We identified vaccinations, ER visits and admissions using health administrative data housed at the Institute for Clinical Evaluative Sciences. We used the self-controlled case series design to compare the relative incidence (RI) of events among 1(st)-born and later-born children using relative incidence ratios (RIR).<h4>Results</h4>For the 2-month vaccination, the RIR for 1(st)-borns versus later-born children was 1.37 (95% CI: 1.19-1.57), which translates to 112 additional events/100,000 vaccinated. For the 4-month vaccination, the RIR for 1(st)-borns vs. later-borns was 1.70 (95% CI: 1.45-1.99), representing 157 additional events/100,000 vaccinated. At 6 months, the RIR for 1(st) vs. later-borns was 1.27 (95% CI: 1.09-1.48), or 77 excess events/100,000 vaccinated. At the 12-month vaccination, the RIR was 1.11 (95% CI: 1.02-1.21), or 249 excess events/100,000 vaccinated.<h4>Conclusions</h4>Birth order is associated with increased incidence of ER visits and hospitalizations following vaccination in infancy. 1(st)-born children had significantly higher relative incidence of events compared to later-born children.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2021-02-20T19:56:40Z","creation":"2019-03-26T23:17:13Z"},"accession":"S-EPMC3852020","cross_references":{"pubmed":["24324662"],"doi":["10.1371/journal.pone.0081070"]}}