{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Higham A"],"funding":["Biotechnology and Biological Sciences Research Council"],"pubmed_abstract":["<h4>Background</h4>There is a need for novel anti-inflammatory therapies to treat COPD. The liver X receptor (LXR) is a nuclear hormone receptor with anti-inflammatory properties.<h4>Methods</h4>We investigated LXR gene and protein expression levels in alveolar macrophages and whole lung tissue from COPD patients and controls, the effect of LXR activation on the suppression of inflammatory mediators from LPS stimulated COPD alveolar macrophages, and the effect of LXR activation on the induction of genes associated with alternative macrophage polarisation.<h4>Results</h4>The levels of LXR mRNA were significantly increased in whole lung tissue extracts in COPD patients and smokers compared to non-smokers. The expression of LXR protein was significantly increased in small airway epithelium an"],"journal":["Respiratory research"],"pagination":["106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3852990"],"repository":["biostudies-literature"],"pubmed_title":["The role of the liver X receptor in chronic obstructive pulmonary disease."],"pmcid":["PMC3852990"],"pubmed_authors":["Higham A","Maschera B","Lea S","Plumb J","Singh D","Simpson K","Ray D"],"additional_accession":[]},"is_claimable":false,"name":"The role of the liver X receptor in chronic obstructive pulmonary disease.","description":"<h4>Background</h4>There is a need for novel anti-inflammatory therapies to treat COPD. The liver X receptor (LXR) is a nuclear hormone receptor with anti-inflammatory properties.<h4>Methods</h4>We investigated LXR gene and protein expression levels in alveolar macrophages and whole lung tissue from COPD patients and controls, the effect of LXR activation on the suppression of inflammatory mediators from LPS stimulated COPD alveolar macrophages, and the effect of LXR activation on the induction of genes associated with alternative macrophage polarisation.<h4>Results</h4>The levels of LXR mRNA were significantly increased in whole lung tissue extracts in COPD patients and smokers compared to non-smokers. The expression of LXR protein was significantly increased in small airway epithelium an","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Oct","modification":"2025-04-22T16:39:12.513Z","creation":"2019-03-27T03:09:51Z"},"accession":"S-EPMC3852990","cross_references":{"pubmed":["24118845"],"doi":["10.1186/1465-9921-14-106"]}}