{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Palsson S"],"pubmed_abstract":["<h4>Background</h4>The complexity and multiscale nature of the mammalian immune response provides an excellent test bed for the potential of mathematical modeling and simulation to facilitate mechanistic understanding. Historically, mathematical models of the immune response focused on subsets of the immune system and/or specific aspects of the response. Mathematical models have been developed for the humoral side of the immune response, or for the cellular side, or for cytokine kinetics, but rarely have they been proposed to encompass the overall system complexity. We propose here a framework for integration of subset models, based on a system biology approach.<h4>Results</h4>A dynamic simulator, the Fully-integrated Immune Response Model (FIRM), was built in a stepwise fashion by integra"],"journal":["BMC systems biology"],"pagination":["95"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3853972"],"repository":["biostudies-literature"],"pubmed_title":["The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models."],"pmcid":["PMC3853972"],"pubmed_authors":["Palsson S","Spilker ME","O'Brien PJ","Vicini P","Zager M","Palsson BO","Hickling TP","Jooss K","Bradshaw-Pierce EL"],"additional_accession":[]},"is_claimable":false,"name":"The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models.","description":"<h4>Background</h4>The complexity and multiscale nature of the mammalian immune response provides an excellent test bed for the potential of mathematical modeling and simulation to facilitate mechanistic understanding. Historically, mathematical models of the immune response focused on subsets of the immune system and/or specific aspects of the response. Mathematical models have been developed for the humoral side of the immune response, or for the cellular side, or for cytokine kinetics, but rarely have they been proposed to encompass the overall system complexity. We propose here a framework for integration of subset models, based on a system biology approach.<h4>Results</h4>A dynamic simulator, the Fully-integrated Immune Response Model (FIRM), was built in a stepwise fashion by integra","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Sep","modification":"2025-04-22T16:36:33.548Z","creation":"2019-03-27T01:18:06Z"},"accession":"S-EPMC3853972","cross_references":{"pubmed":["24074340"],"doi":["10.1186/1752-0509-7-95"]}}