{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hickey AC"],"funding":["PHS HHS"],"pagination":["1043-57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3854881"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["89(6)"],"pubmed_abstract":["Dengue virus (DENV) is considered to be the most important arthropod-borne viral disease and causes more than 100 million human infections annually. To further characterize primary DENV infection in vivo, rhesus macaques were infected with DENV-1, DENV-2, DENV-3, or DENV-4 and clinical parameters, as well as specificity and longevity of serologic responses, were assessed. Overt clinical symptoms were not present after infection. However, abnormalities in blood biochemical parameters consistent with heart, kidney, and liver damage were observed, and changes in plasma fibrinogen, D-dimers, and protein C indicated systemic activation of the blood coagulation pathway. Significant homotypic and heterotypic serum immunoglobulins were present in all animals, and IgG persisted for at least 390 day"],"journal":["The American journal of tropical medicine and hygiene"],"pubmed_title":["Serotype-specific host responses in rhesus macaques after primary dengue challenge."],"pmcid":["PMC3854881"],"funding_grant_id":["HSN272201000007I-HHSN27200001"],"pubmed_authors":["Koster JA","Hickey AC","Cardosa MJ","Thalmann CM","Bossart KN","Hardcastle K","Tio PH"],"additional_accession":[]},"is_claimable":false,"name":"Serotype-specific host responses in rhesus macaques after primary dengue challenge.","description":"Dengue virus (DENV) is considered to be the most important arthropod-borne viral disease and causes more than 100 million human infections annually. To further characterize primary DENV infection in vivo, rhesus macaques were infected with DENV-1, DENV-2, DENV-3, or DENV-4 and clinical parameters, as well as specificity and longevity of serologic responses, were assessed. Overt clinical symptoms were not present after infection. However, abnormalities in blood biochemical parameters consistent with heart, kidney, and liver damage were observed, and changes in plasma fibrinogen, D-dimers, and protein C indicated systemic activation of the blood coagulation pathway. Significant homotypic and heterotypic serum immunoglobulins were present in all animals, and IgG persisted for at least 390 day","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Dec","modification":"2025-04-04T12:47:15.387Z","creation":"2019-03-27T01:18:08Z"},"accession":"S-EPMC3854881","cross_references":{"pubmed":["24062475"],"doi":["10.4269/ajtmh.13-0145"]}}