{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Sette A"],"pubmed_abstract":["Titanium dioxide (TiO<sub>2</sub>) has been widely used in many nanotechnology areas including nanomedicine, where it could be proposed for the photodynamic and sonodynamic cancer therapies. However, TiO<sub>2</sub> nanoformulations have been shown to be toxic for living cells. In this article, we report the development of a new delivery system, based on nontoxic TiO<sub>2</sub> nanoparticles, further conjugated with a monoclonal antibody against a novel and easily accessible tumor marker, e.g., the Kv 11.1 potassium channel. We synthesized, by simple solvothermal method, dicarboxylic acid-terminated PEG TiO<sub>2</sub> nanocrystals (PEG-TiO<sub>2</sub> NPs). Anti-Kv 11.1 monoclonal antibodies (Kv 11.1-Mab) were further linked to the terminal carboxylic acid groups. Proper conjugation was "],"journal":["Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology"],"pagination":["2111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3857862"],"repository":["biostudies-literature"],"pubmed_title":["Development of novel anti-Kv 11.1 antibody-conjugated PEG-TiO<sub>2</sub> nanoparticles for targeting pancreatic ductal adenocarcinoma cells."],"pmcid":["PMC3857862"],"pubmed_authors":["Crociani O","Sette A","Spadavecchia J","Landoulsi J","Casale S","Arcangeli A","Haye B"],"additional_accession":[]},"is_claimable":false,"name":"Development of novel anti-Kv 11.1 antibody-conjugated PEG-TiO<sub>2</sub> nanoparticles for targeting pancreatic ductal adenocarcinoma cells.","description":"Titanium dioxide (TiO<sub>2</sub>) has been widely used in many nanotechnology areas including nanomedicine, where it could be proposed for the photodynamic and sonodynamic cancer therapies. However, TiO<sub>2</sub> nanoformulations have been shown to be toxic for living cells. In this article, we report the development of a new delivery system, based on nontoxic TiO<sub>2</sub> nanoparticles, further conjugated with a monoclonal antibody against a novel and easily accessible tumor marker, e.g., the Kv 11.1 potassium channel. We synthesized, by simple solvothermal method, dicarboxylic acid-terminated PEG TiO<sub>2</sub> nanocrystals (PEG-TiO<sub>2</sub> NPs). Anti-Kv 11.1 monoclonal antibodies (Kv 11.1-Mab) were further linked to the terminal carboxylic acid groups. Proper conjugation was ","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-04T07:25:24.694Z","creation":"2019-03-27T01:18:16Z"},"accession":"S-EPMC3857862","cross_references":{"pubmed":["24348091"],"doi":["10.1007/s11051-013-2111-6"]}}