biostudies-literatureUnknown15Sette ATitanium dioxide (TiO<sub>2</sub>) has been widely used in many nanotechnology areas including nanomedicine, where it could be proposed for the photodynamic and sonodynamic cancer therapies. However, TiO<sub>2</sub> nanoformulations have been shown to be toxic for living cells. In this article, we report the development of a new delivery system, based on nontoxic TiO<sub>2</sub> nanoparticles, further conjugated with a monoclonal antibody against a novel and easily accessible tumor marker, e.g., the Kv 11.1 potassium channel. We synthesized, by simple solvothermal method, dicarboxylic acid-terminated PEG TiO<sub>2</sub> nanocrystals (PEG-TiO<sub>2</sub> NPs). Anti-Kv 11.1 monoclonal antibodies (Kv 11.1-Mab) were further linked to the terminal carboxylic acid groups. Proper conjugation was Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology2111https://www.ebi.ac.uk/biostudies/studies/S-EPMC3857862biostudies-literatureDevelopment of novel anti-Kv 11.1 antibody-conjugated PEG-TiO<sub>2</sub> nanoparticles for targeting pancreatic ductal adenocarcinoma cells.PMC3857862Crociani OSette ASpadavecchia JLandoulsi JCasale SArcangeli AHaye BfalseDevelopment of novel anti-Kv 11.1 antibody-conjugated PEG-TiO<sub>2</sub> nanoparticles for targeting pancreatic ductal adenocarcinoma cells.Titanium dioxide (TiO<sub>2</sub>) has been widely used in many nanotechnology areas including nanomedicine, where it could be proposed for the photodynamic and sonodynamic cancer therapies. However, TiO<sub>2</sub> nanoformulations have been shown to be toxic for living cells. In this article, we report the development of a new delivery system, based on nontoxic TiO<sub>2</sub> nanoparticles, further conjugated with a monoclonal antibody against a novel and easily accessible tumor marker, e.g., the Kv 11.1 potassium channel. We synthesized, by simple solvothermal method, dicarboxylic acid-terminated PEG TiO<sub>2</sub> nanocrystals (PEG-TiO<sub>2</sub> NPs). Anti-Kv 11.1 monoclonal antibodies (Kv 11.1-Mab) were further linked to the terminal carboxylic acid groups. Proper conjugation was 2013-01-01T00:00:00Z20132025-04-04T07:25:24.694Z2019-03-27T01:18:16ZS-EPMC38578622434809110.1007/s11051-013-2111-6