{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Pope SM"],"pubmed_abstract":["Until recently thought to be of little significance unless occurring during pregnancy, Toxoplasma gondii infection of human hosts is now known to play a larger role in mental health and is a growing concern in the health care community. We sought to elucidate a possible mechanism by which Toxoplasma infection may cause some of the behavioural pathology now associated with infection. We hypothesized that exosomes may be playing a role. We utilized electron microscopy to detect the presence and size of extracellular vesicles in the supernatants of Toxoplasma-infected human foreskin fibroblasts (HFF). We then utilized microarray analysis to discern mRNA and miRNA content of the vesicles isolated from supernatants of Toxoplasma-infected (Toxo) and serum-starved (SS) HFF. We recovered extracell"],"journal":["Journal of extracellular vesicles"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3862870"],"repository":["biostudies-literature"],"pubmed_title":["Toxoplasma gondii infection of fibroblasts causes the production of exosome-like vesicles containing a unique array of mRNA and miRNA transcripts compared to serum starvation."],"pmcid":["PMC3862870"],"pubmed_authors":["Lasser C","Pope SM"],"additional_accession":[]},"is_claimable":false,"name":"Toxoplasma gondii infection of fibroblasts causes the production of exosome-like vesicles containing a unique array of mRNA and miRNA transcripts compared to serum starvation.","description":"Until recently thought to be of little significance unless occurring during pregnancy, Toxoplasma gondii infection of human hosts is now known to play a larger role in mental health and is a growing concern in the health care community. We sought to elucidate a possible mechanism by which Toxoplasma infection may cause some of the behavioural pathology now associated with infection. We hypothesized that exosomes may be playing a role. We utilized electron microscopy to detect the presence and size of extracellular vesicles in the supernatants of Toxoplasma-infected human foreskin fibroblasts (HFF). We then utilized microarray analysis to discern mRNA and miRNA content of the vesicles isolated from supernatants of Toxoplasma-infected (Toxo) and serum-starved (SS) HFF. We recovered extracell","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-04T18:51:06.167Z","creation":"2019-06-05T19:45:47Z"},"accession":"S-EPMC3862870","cross_references":{"pubmed":["24363837"],"doi":["10.3402/jev.v2i0.22484"]}}