{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Low HZ"],"pubmed_abstract":["LILRA3 is the sole soluble member of the LILR family. Previous studies from our group had shown that a 6.7 kb genetic deletion of LILRA3 is associated with MS and Sjögren's syndrome. An impairment of the immune response leads to a predisposition for B-NHL, so we wanted to study whether the deletion of LILRA3 is also a risk factor for B-NHL, as well as the function of LILRA3. We discovered that the frequency of the homozygous LILRA3 deletion was significantly higher in B-NHL (6%) than in blood donors (3%) (P = 0.03). We detected binding of fluorochrome-conjugated recombinant LILRA3 to monocytes and B-cells. Incubation of PBMCs with recombinant LILRA3 induced proliferation of CD8(+) T-cells and NK cells, as determined by CFSE staining. Using a transwell system, we demonstrated that LILRA3-st"],"journal":["PloS one"],"pagination":["e81360"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3867304"],"repository":["biostudies-literature"],"pubmed_title":["Association of the LILRA3 deletion with B-NHL and functional characterization of the immunostimulatory molecule."],"pmcid":["PMC3867304"],"pubmed_authors":["Peest D","Schmidt RE","Witte T","Matthias T","Stripecke R","Topperwien M","Dankenbrink N","Low HZ","Reuter S","Kabalak G"],"additional_accession":[]},"is_claimable":false,"name":"Association of the LILRA3 deletion with B-NHL and functional characterization of the immunostimulatory molecule.","description":"LILRA3 is the sole soluble member of the LILR family. Previous studies from our group had shown that a 6.7 kb genetic deletion of LILRA3 is associated with MS and Sjögren's syndrome. An impairment of the immune response leads to a predisposition for B-NHL, so we wanted to study whether the deletion of LILRA3 is also a risk factor for B-NHL, as well as the function of LILRA3. We discovered that the frequency of the homozygous LILRA3 deletion was significantly higher in B-NHL (6%) than in blood donors (3%) (P = 0.03). We detected binding of fluorochrome-conjugated recombinant LILRA3 to monocytes and B-cells. Incubation of PBMCs with recombinant LILRA3 induced proliferation of CD8(+) T-cells and NK cells, as determined by CFSE staining. Using a transwell system, we demonstrated that LILRA3-st","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-21T16:59:34.798Z","creation":"2019-03-26T23:17:24Z"},"accession":"S-EPMC3867304","cross_references":{"pubmed":["24363809"],"doi":["10.1371/journal.pone.0081360"]}}