biostudies-literatureUnknown8(12)Low HZLILRA3 is the sole soluble member of the LILR family. Previous studies from our group had shown that a 6.7 kb genetic deletion of LILRA3 is associated with MS and Sjögren's syndrome. An impairment of the immune response leads to a predisposition for B-NHL, so we wanted to study whether the deletion of LILRA3 is also a risk factor for B-NHL, as well as the function of LILRA3. We discovered that the frequency of the homozygous LILRA3 deletion was significantly higher in B-NHL (6%) than in blood donors (3%) (P = 0.03). We detected binding of fluorochrome-conjugated recombinant LILRA3 to monocytes and B-cells. Incubation of PBMCs with recombinant LILRA3 induced proliferation of CD8(+) T-cells and NK cells, as determined by CFSE staining. Using a transwell system, we demonstrated that LILRA3-stPloS onee81360https://www.ebi.ac.uk/biostudies/studies/S-EPMC3867304biostudies-literatureAssociation of the LILRA3 deletion with B-NHL and functional characterization of the immunostimulatory molecule.PMC3867304Peest DSchmidt REWitte TMatthias TStripecke RTopperwien MDankenbrink NLow HZReuter SKabalak GfalseAssociation of the LILRA3 deletion with B-NHL and functional characterization of the immunostimulatory molecule.LILRA3 is the sole soluble member of the LILR family. Previous studies from our group had shown that a 6.7 kb genetic deletion of LILRA3 is associated with MS and Sjögren's syndrome. An impairment of the immune response leads to a predisposition for B-NHL, so we wanted to study whether the deletion of LILRA3 is also a risk factor for B-NHL, as well as the function of LILRA3. We discovered that the frequency of the homozygous LILRA3 deletion was significantly higher in B-NHL (6%) than in blood donors (3%) (P = 0.03). We detected binding of fluorochrome-conjugated recombinant LILRA3 to monocytes and B-cells. Incubation of PBMCs with recombinant LILRA3 induced proliferation of CD8(+) T-cells and NK cells, as determined by CFSE staining. Using a transwell system, we demonstrated that LILRA3-st2013-01-01T00:00:00Z20132025-04-21T16:59:34.798Z2019-03-26T23:17:24ZS-EPMC38673042436380910.1371/journal.pone.0081360