{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":47,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["63(1)"],"submitter":["Hanson RL"],"funding":["Intramural NIH HHS"],"pubmed_abstract":["Most genetic variants associated with type 2 diabetes mellitus (T2DM) have been identified through genome-wide association studies (GWASs) in Europeans. The current study reports a GWAS for young-onset T2DM in American Indians. Participants were selected from a longitudinal study conducted in Pima Indians and included 278 cases with diabetes with onset before 25 years of age, 295 nondiabetic controls ≥45 years of age, and 267 siblings of cases or controls. Individuals were genotyped on a ∼1M single nucleotide polymorphism (SNP) array, resulting in 453,654 SNPs with minor allele frequency >0.05. SNPs were analyzed for association in cases and controls, and a family-based association test was conducted. Tag SNPs (n = 311) were selected for 499 SNPs associated with diabetes (P < 0.0005 in case-control analyses or P < 0.0003 in family-based analyses), and these SNPs were genotyped in up to 6,834 additional Pima Indians to assess replication. Rs1861612 in DNER was associated with T2DM (odds ratio = 1.29 per copy of the T allele; P = 6.6 × 10(-8), which represents genome-wide significance accounting for the number of effectively independent SNPs analyzed). Transfection studies in murine pancreatic β-cells suggested that DNER regulates expression of notch signaling pathway genes. These studies implicate DNER as a susceptibility gene for T2DM in American Indians."],"journal":["Diabetes"],"pagination":["369-76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3868048"],"repository":["biostudies-literature"],"pubmed_title":["A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes."],"pmcid":["PMC3868048"],"pubmed_authors":["Weil EJ","Nelson RG","Guo T","Ossowski V","Huang K","Abdussamad M","Bogardus C","Kobes S","Muller YL","Wiedrich K","Bian L","Hanson RL","Mahkee D","Bennett PH","Wiedrich C","Knowler WC","Sutherland J","Baier LJ","Traurig M"],"view_count":["47"],"additional_accession":[]},"is_claimable":false,"name":"A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.","description":"Most genetic variants associated with type 2 diabetes mellitus (T2DM) have been identified through genome-wide association studies (GWASs) in Europeans. The current study reports a GWAS for young-onset T2DM in American Indians. Participants were selected from a longitudinal study conducted in Pima Indians and included 278 cases with diabetes with onset before 25 years of age, 295 nondiabetic controls ≥45 years of age, and 267 siblings of cases or controls. Individuals were genotyped on a ∼1M single nucleotide polymorphism (SNP) array, resulting in 453,654 SNPs with minor allele frequency >0.05. SNPs were analyzed for association in cases and controls, and a family-based association test was conducted. Tag SNPs (n = 311) were selected for 499 SNPs associated with diabetes (P < 0.0005 in case-control analyses or P < 0.0003 in family-based analyses), and these SNPs were genotyped in up to 6,834 additional Pima Indians to assess replication. Rs1861612 in DNER was associated with T2DM (odds ratio = 1.29 per copy of the T allele; P = 6.6 × 10(-8), which represents genome-wide significance accounting for the number of effectively independent SNPs analyzed). Transfection studies in murine pancreatic β-cells suggested that DNER regulates expression of notch signaling pathway genes. These studies implicate DNER as a susceptibility gene for T2DM in American Indians.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jan","modification":"2024-11-20T19:52:20.358Z","creation":"2019-03-27T01:18:43Z"},"accession":"S-EPMC3868048","cross_references":{"pubmed":["24101674"],"doi":["10.2337/db13-0416"]}}