{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dranoff JA"],"funding":["Yale Liver Center","NIDDK NIH HHS","National Institutes of Health","NIDDK"],"pagination":["e00125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3871447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(6)"],"pubmed_abstract":["Liver myofibroblasts derived from hepatic stellate cells (HSC) are critical mediators of liver fibrosis. Release of tissue inhibitor of metalloproteinase-1 (TIMP-1) advances liver fibrosis by blocking fibrinolysis. The mechanisms responsible for the posttranslational regulation of TIMP-1 by myofibroblastic HSC are unknown. Here, we demonstrate that TIMP-1 release by HSC is regulated in a posttranslational fashion via calcium-sensitive vesicular exocytosis. To our knowledge, this is the first article to directly examine vesicular trafficking in myofibroblastic HSC, potentially providing a new target to treat and or prevent liver fibrosis."],"journal":["Physiological reports"],"pubmed_title":["Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis."],"pmcid":["PMC3871447"],"funding_grant_id":["DK45710","DK076735","R01 DK076735"],"pubmed_authors":["Bhatia N","Dranoff JA","Fausther M","Baldini G","Granell S","Lavoie EG","Sheung N","Hickman DA"],"additional_accession":[]},"is_claimable":false,"name":"Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis.","description":"Liver myofibroblasts derived from hepatic stellate cells (HSC) are critical mediators of liver fibrosis. Release of tissue inhibitor of metalloproteinase-1 (TIMP-1) advances liver fibrosis by blocking fibrinolysis. The mechanisms responsible for the posttranslational regulation of TIMP-1 by myofibroblastic HSC are unknown. Here, we demonstrate that TIMP-1 release by HSC is regulated in a posttranslational fashion via calcium-sensitive vesicular exocytosis. To our knowledge, this is the first article to directly examine vesicular trafficking in myofibroblastic HSC, potentially providing a new target to treat and or prevent liver fibrosis.","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Nov","modification":"2025-04-22T01:14:04.323Z","creation":"2019-03-27T01:18:56Z"},"accession":"S-EPMC3871447","cross_references":{"pubmed":["24400134"],"doi":["10.1002/phy2.125"]}}