biostudies-literatureUnknown13(1)Hjerpe E<h4>Background</h4>A deregulated energy metabolism is a hallmark of malignant disease that offers possible future targets for treatment. We investigated the prognostic value of the glycolytic enzymes glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and pyruvate kinase type M2 (PKM2), mitochondrial β-F1-ATPase (ATP5B) and the bioenergetic cellular (BEC) index in advanced ovarian cancer.<h4>Methods</h4>Fresh tumor samples were prospectively collected from 123 patients undergoing primary surgery for suspected advanced ovarian cancer. Of these, 57 met the eligibility criteria; stage IIC-IV, serous or endometrioid subtype, specimens containing ≥ 50% tumor cells and patients receiving platinum-based chemotherapy. An adequate amount of mRNA could be extracted in all but one case, with a resultantBMC clinical pathology30https://www.ebi.ac.uk/biostudies/studies/S-EPMC3874631biostudies-literatureMetabolic markers GAPDH, PKM2, ATP5B and BEC-index in advanced serous ovarian cancer.PMC3874631Carlson JJohansson HEgyhazi Brage SHjerpe EAvall-Lundqvist EFrostvik Stolt MShoshan MSchedvins KfalseMetabolic markers GAPDH, PKM2, ATP5B and BEC-index in advanced serous ovarian cancer.<h4>Background</h4>A deregulated energy metabolism is a hallmark of malignant disease that offers possible future targets for treatment. We investigated the prognostic value of the glycolytic enzymes glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and pyruvate kinase type M2 (PKM2), mitochondrial β-F1-ATPase (ATP5B) and the bioenergetic cellular (BEC) index in advanced ovarian cancer.<h4>Methods</h4>Fresh tumor samples were prospectively collected from 123 patients undergoing primary surgery for suspected advanced ovarian cancer. Of these, 57 met the eligibility criteria; stage IIC-IV, serous or endometrioid subtype, specimens containing ≥ 50% tumor cells and patients receiving platinum-based chemotherapy. An adequate amount of mRNA could be extracted in all but one case, with a resultant2013-01-01T00:00:00Z2013 Nov2025-04-04T22:17:35.535Z2019-03-27T01:19:07ZS-EPMC38746312425213710.1186/1472-6890-13-30