{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Maheandiran M"],"pubmed_abstract":["It is well accepted that insulin-induced hypoglycemia can result in seizures. However, the effects of the seizures, as well as possible treatment strategies, have yet to be elucidated, particularly in juvenile or insulin-dependent diabetes mellitus (IDDM). Here we establish a model of diabetes in young rats, to examine the consequences of severe hypoglycemia in this age group; particularly seizures and mortality. Diabetes was induced in post-weaned 22-day-old Sprague-Dawley rats by streptozotocin (STZ) administered intraperitoneally (IP). Insulin IP (15 U/kg), in rats fasted (14-16 hours), induced hypoglycemia, defined as <3.5 mM blood glucose (BG), in 68% of diabetic (STZ) and 86% of control rats (CON). Seizures occurred in 86% of STZ and all CON rats that reached hypoglycemic levels with"],"journal":["PloS one"],"pagination":["e83168"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3875447"],"repository":["biostudies-literature"],"pubmed_title":["Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality."],"pmcid":["PMC3875447"],"pubmed_authors":["Sugumar S","Maheandiran M","Carlen PL","del Campo M","El-Hayek Y","Wu C","Giacca A","Mylvaganam S","Zhang L","Hazrati L"],"additional_accession":[]},"is_claimable":false,"name":"Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality.","description":"It is well accepted that insulin-induced hypoglycemia can result in seizures. However, the effects of the seizures, as well as possible treatment strategies, have yet to be elucidated, particularly in juvenile or insulin-dependent diabetes mellitus (IDDM). Here we establish a model of diabetes in young rats, to examine the consequences of severe hypoglycemia in this age group; particularly seizures and mortality. Diabetes was induced in post-weaned 22-day-old Sprague-Dawley rats by streptozotocin (STZ) administered intraperitoneally (IP). Insulin IP (15 U/kg), in rats fasted (14-16 hours), induced hypoglycemia, defined as <3.5 mM blood glucose (BG), in 68% of diabetic (STZ) and 86% of control rats (CON). Seizures occurred in 86% of STZ and all CON rats that reached hypoglycemic levels with","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-26T09:59:51.779Z","creation":"2019-03-26T23:21:20Z"},"accession":"S-EPMC3875447","cross_references":{"pubmed":["24386156"],"doi":["10.1371/journal.pone.0083168"]}}