{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(12)"],"submitter":["Chen S"],"pubmed_abstract":["<h4>Background</h4>Ras homolog gene family member A (RhoA) is involved in Wnt-5a-induced migration of gastric and breast cancer cells. We investigated the roles of RhoA and Wnt-5a in ovarian carcinoma.<h4>Methods</h4>RhoA and Wnt-5a mRNA and protein expression in normal fallopian tube epithelium, benign tumors, primary ovarian carcinomas, and metastatic omentum were quantified. RhoA or Wnt-5a was knocked down in OVCAR3 ovarian carcinoma cells using siRNAs and cell phenotype and expression of relevant molecules were assayed.<h4>Results</h4>RhoA and Wnt-5a mRNA and protein expression were found to be significantly higher in metastatic omentum than in ovarian carcinomas, benign tumors, and normal fallopian tube epithelium (p < 0.05), and positively associated with differentiation and FIGO sta"],"journal":["International journal of molecular sciences"],"pagination":["24187-99"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3876104"],"repository":["biostudies-literature"],"pubmed_title":["The involvement of RhoA and Wnt-5a in the tumorigenesis and progression of ovarian epithelial carcinoma."],"pmcid":["PMC3876104"],"pubmed_authors":["Zheng HC","Xiu YL","Zong ZH","Gou WF","Chen S","Wang J","Takano Y","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"The involvement of RhoA and Wnt-5a in the tumorigenesis and progression of ovarian epithelial carcinoma.","description":"<h4>Background</h4>Ras homolog gene family member A (RhoA) is involved in Wnt-5a-induced migration of gastric and breast cancer cells. We investigated the roles of RhoA and Wnt-5a in ovarian carcinoma.<h4>Methods</h4>RhoA and Wnt-5a mRNA and protein expression in normal fallopian tube epithelium, benign tumors, primary ovarian carcinomas, and metastatic omentum were quantified. RhoA or Wnt-5a was knocked down in OVCAR3 ovarian carcinoma cells using siRNAs and cell phenotype and expression of relevant molecules were assayed.<h4>Results</h4>RhoA and Wnt-5a mRNA and protein expression were found to be significantly higher in metastatic omentum than in ovarian carcinomas, benign tumors, and normal fallopian tube epithelium (p < 0.05), and positively associated with differentiation and FIGO sta","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Dec","modification":"2025-04-26T09:55:09.149Z","creation":"2019-03-27T01:19:09Z"},"accession":"S-EPMC3876104","cross_references":{"pubmed":["24351810"],"doi":["10.3390/ijms141224187"]}}