biostudies-literatureUnknown14(12)Chen S<h4>Background</h4>Ras homolog gene family member A (RhoA) is involved in Wnt-5a-induced migration of gastric and breast cancer cells. We investigated the roles of RhoA and Wnt-5a in ovarian carcinoma.<h4>Methods</h4>RhoA and Wnt-5a mRNA and protein expression in normal fallopian tube epithelium, benign tumors, primary ovarian carcinomas, and metastatic omentum were quantified. RhoA or Wnt-5a was knocked down in OVCAR3 ovarian carcinoma cells using siRNAs and cell phenotype and expression of relevant molecules were assayed.<h4>Results</h4>RhoA and Wnt-5a mRNA and protein expression were found to be significantly higher in metastatic omentum than in ovarian carcinomas, benign tumors, and normal fallopian tube epithelium (p < 0.05), and positively associated with differentiation and FIGO staInternational journal of molecular sciences24187-99https://www.ebi.ac.uk/biostudies/studies/S-EPMC3876104biostudies-literatureThe involvement of RhoA and Wnt-5a in the tumorigenesis and progression of ovarian epithelial carcinoma.PMC3876104Zheng HCXiu YLZong ZHGou WFChen SWang JTakano YZhao YfalseThe involvement of RhoA and Wnt-5a in the tumorigenesis and progression of ovarian epithelial carcinoma.<h4>Background</h4>Ras homolog gene family member A (RhoA) is involved in Wnt-5a-induced migration of gastric and breast cancer cells. We investigated the roles of RhoA and Wnt-5a in ovarian carcinoma.<h4>Methods</h4>RhoA and Wnt-5a mRNA and protein expression in normal fallopian tube epithelium, benign tumors, primary ovarian carcinomas, and metastatic omentum were quantified. RhoA or Wnt-5a was knocked down in OVCAR3 ovarian carcinoma cells using siRNAs and cell phenotype and expression of relevant molecules were assayed.<h4>Results</h4>RhoA and Wnt-5a mRNA and protein expression were found to be significantly higher in metastatic omentum than in ovarian carcinomas, benign tumors, and normal fallopian tube epithelium (p < 0.05), and positively associated with differentiation and FIGO sta2013-01-01T00:00:00Z2013 Dec2025-04-26T09:55:09.149Z2019-03-27T01:19:09ZS-EPMC38761042435181010.3390/ijms141224187