{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Venkataramanan KP"],"pubmed_abstract":["<h4>Background</h4>Small non-coding RNAs (sRNA) are emerging as major components of the cell's regulatory network, several possessing their own regulons. A few sRNAs have been reported as being involved in general or toxic-metabolite stress, mostly in Gram- prokaryotes, but hardly any in Gram+ prokaryotes. Significantly, the role of sRNAs in the stress response remains poorly understood at the genome-scale level. It was previously shown that toxic-metabolite stress is one of the most comprehensive and encompassing stress responses in the cell, engaging both the general stress (or heat-shock protein, HSP) response as well as specialized metabolic programs.<h4>Results</h4>Using RNA deep sequencing (RNA-seq) we examined the sRNome of C. acetobutylicum in response to the native but toxic metab"],"journal":["BMC genomics"],"pagination":["849"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3879012"],"repository":["biostudies-literature"],"pubmed_title":["The Clostridium small RNome that responds to stress: the paradigm and importance of toxic metabolite stress in C. acetobutylicum."],"pmcid":["PMC3879012"],"pubmed_authors":["McCormick KP","Papoutsakis ET","Ralston MT","Kunjeti SG","Venkataramanan KP","Jones SW","Meyers BC"],"additional_accession":[]},"is_claimable":false,"name":"The Clostridium small RNome that responds to stress: the paradigm and importance of toxic metabolite stress in C. acetobutylicum.","description":"<h4>Background</h4>Small non-coding RNAs (sRNA) are emerging as major components of the cell's regulatory network, several possessing their own regulons. A few sRNAs have been reported as being involved in general or toxic-metabolite stress, mostly in Gram- prokaryotes, but hardly any in Gram+ prokaryotes. Significantly, the role of sRNAs in the stress response remains poorly understood at the genome-scale level. It was previously shown that toxic-metabolite stress is one of the most comprehensive and encompassing stress responses in the cell, engaging both the general stress (or heat-shock protein, HSP) response as well as specialized metabolic programs.<h4>Results</h4>Using RNA deep sequencing (RNA-seq) we examined the sRNome of C. acetobutylicum in response to the native but toxic metab","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Dec","modification":"2026-04-16T07:07:00.581Z","creation":"2026-04-07T14:08:14.496Z"},"accession":"S-EPMC3879012","cross_references":{"pubmed":["24299206"],"doi":["10.1186/1471-2164-14-849"]}}