{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["71(2)"],"submitter":["Hua SS"],"pubmed_abstract":["Previous results demonstrated that the capR (lon) locus, which is not linked to the gal operon, independently controls the synthesis of the gal operon enzymes and gal mRNA, i.e., galO(+)capR9 strains are derepressed 4- to 6-fold as compared to galO(+)capR(+) strains. A mutation has been isolated and localized in the galactose operator region that defines a new and distinct site of control. Mutation in this site, designated galO(capR+), causes a 4-fold increase in the galactose enzymes, galactokinase (EC 2.7.1.6) and UDP-galactose-4-epimerase (EC 5.1.3.2), in a capR(+) background. These mutants exhibit a reduced response to regulation by the unlinked regulator gene capR (lon). However, the galO(capR+) mutants are still subject to control by the galR repressor, since they can be further dere"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["507-11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC388036"],"repository":["biostudies-literature"],"pubmed_title":["Multiple regulation of the galactose operon-genetic evidence for a distinct site in the galactose operon that responds to capR gene regulation in Escherichia coli K-12."],"pmcid":["PMC388036"],"pubmed_authors":["Hua SS","Markovitz A"],"additional_accession":[]},"is_claimable":false,"name":"Multiple regulation of the galactose operon-genetic evidence for a distinct site in the galactose operon that responds to capR gene regulation in Escherichia coli K-12.","description":"Previous results demonstrated that the capR (lon) locus, which is not linked to the gal operon, independently controls the synthesis of the gal operon enzymes and gal mRNA, i.e., galO(+)capR9 strains are derepressed 4- to 6-fold as compared to galO(+)capR(+) strains. A mutation has been isolated and localized in the galactose operator region that defines a new and distinct site of control. Mutation in this site, designated galO(capR+), causes a 4-fold increase in the galactose enzymes, galactokinase (EC 2.7.1.6) and UDP-galactose-4-epimerase (EC 5.1.3.2), in a capR(+) background. These mutants exhibit a reduced response to regulation by the unlinked regulator gene capR (lon). However, the galO(capR+) mutants are still subject to control by the galR repressor, since they can be further dere","dates":{"release":"1974-01-01T00:00:00Z","publication":"1974 Feb","modification":"2025-04-18T16:45:16.068Z","creation":"2025-04-07T04:08:04.273Z"},"accession":"S-EPMC388036","cross_references":{"pubmed":["4360947"],"doi":["10.1073/pnas.71.2.507"]}}