{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Ye P"],"pubmed_abstract":["<h4>Objective</h4>miR-126, the miRNA considered to be specially expressed in endothelial cells and hematopoietic progenitor cells, is strongly associated with angiogenesis. The purpose is to evaluate the role of miR-126 in hypoxia-induced angiogenesis and the possible mechanisms.<h4>Methods</h4>The expression of miR-126 was detected in hypoxia-treated RF/6A cells and diabetic retinas using real-time PCR. The miR-126 was up- or down-regulated by transfecting miR-126-mimics or inhibitors into RF/6A cells. Cell cycle analysis was performed using flow cytometry. The protein levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) were assessed by immunoblotting.<h4>Results</h4>A significantly decreased expression of miR-126 was found in hypoxia-treated RF/6A c"],"journal":["International journal of medical sciences"],"pagination":["17-23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3880987"],"repository":["biostudies-literature"],"pubmed_title":["Hypoxia-induced deregulation of miR-126 and its regulative effect on VEGF and MMP-9 expression."],"pmcid":["PMC3880987"],"pubmed_authors":["He F","Yao K","Liu J","Ye P","Xu W"],"additional_accession":[]},"is_claimable":false,"name":"Hypoxia-induced deregulation of miR-126 and its regulative effect on VEGF and MMP-9 expression.","description":"<h4>Objective</h4>miR-126, the miRNA considered to be specially expressed in endothelial cells and hematopoietic progenitor cells, is strongly associated with angiogenesis. The purpose is to evaluate the role of miR-126 in hypoxia-induced angiogenesis and the possible mechanisms.<h4>Methods</h4>The expression of miR-126 was detected in hypoxia-treated RF/6A cells and diabetic retinas using real-time PCR. The miR-126 was up- or down-regulated by transfecting miR-126-mimics or inhibitors into RF/6A cells. Cell cycle analysis was performed using flow cytometry. The protein levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) were assessed by immunoblotting.<h4>Results</h4>A significantly decreased expression of miR-126 was found in hypoxia-treated RF/6A c","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-18T18:18:18.621Z","creation":"2019-03-27T01:19:25Z"},"accession":"S-EPMC3880987","cross_references":{"pubmed":["24396282"],"doi":["10.7150/ijms.7329"]}}