{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["71(2)"],"submitter":["Sosna J"],"pubmed_abstract":["Programmed necrosis is important in many (patho)physiological settings. For specific therapeutic intervention, however, a better knowledge is required whether necrosis occurs through one single \"core program\" or through several independent pathways. Previously, the poly(ADP-ribose) polymerase (PARP) pathway has been suggested as a crucial element of tumor necrosis factor (TNF)-mediated necroptosis. Here, we show that TNF-induced necroptosis and the PARP pathway represent distinct and independent routes to programmed necrosis. First, DNA-alkylating agents such as 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) or methyl methanesulfonate rapidly activate the PARP pathway, whereas this is a late and secondary event in TNF-induced necroptosis. Second, inhibition of the PARP pathway does not protect"],"journal":["Cellular and molecular life sciences : CMLS"],"pagination":["331-48"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3889832"],"repository":["biostudies-literature"],"pubmed_title":["TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death."],"pmcid":["PMC3889832"],"pubmed_authors":["Sosna J","Kabelitz D","Lange A","Linkermann A","Voigt S","Adam D","Mathieu S","Chan FK","Davarnia P","Rittger A","Schutze S","Thon L","Herdegen T"],"additional_accession":[]},"is_claimable":false,"name":"TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death.","description":"Programmed necrosis is important in many (patho)physiological settings. For specific therapeutic intervention, however, a better knowledge is required whether necrosis occurs through one single \"core program\" or through several independent pathways. Previously, the poly(ADP-ribose) polymerase (PARP) pathway has been suggested as a crucial element of tumor necrosis factor (TNF)-mediated necroptosis. Here, we show that TNF-induced necroptosis and the PARP pathway represent distinct and independent routes to programmed necrosis. First, DNA-alkylating agents such as 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) or methyl methanesulfonate rapidly activate the PARP pathway, whereas this is a late and secondary event in TNF-induced necroptosis. Second, inhibition of the PARP pathway does not protect","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jan","modification":"2026-05-07T07:09:06.195Z","creation":"2019-03-27T01:19:55Z"},"accession":"S-EPMC3889832","cross_references":{"pubmed":["23760205"],"doi":["10.1007/s00018-013-1381-6"]}}