{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Davis KM"],"funding":["NCRR NIH HHS","NIGMS NIH HHS"],"pagination":["9161-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3897202"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117(31)"],"pubmed_abstract":["It is well-known that biological samples undergo X-ray-induced degradation. One of the fastest occurring X-ray-induced processes involves redox modifications (reduction or oxidation) of redox-active cofactors in proteins. Here we analyze room-temperature data on the photoreduction of Mn ions in the oxygen-evolving complex (OEC) of photosystem II, one of the most radiation damage-sensitive proteins and a key constituent of natural photosynthesis in plants, green algae, and cyanobacteria. Time-resolved X-ray emission spectroscopy with wavelength-dispersive detection was used to collect data on the progression of X-ray-induced damage. A kinetic model was developed to fit experimental results, and the rate constant for the reduction of OEC Mn(III) and Mn(IV) ions by solvated electrons was dete"],"journal":["The journal of physical chemistry. B"],"pubmed_title":["Kinetic modeling of the X-ray-induced damage to a metalloprotein."],"pmcid":["PMC3897202"],"funding_grant_id":["P41 RR007707","5P41RR007707","P41 GM103543","R24 GM111072","8P41GM103543"],"pubmed_authors":["Henning RW","Seidler GT","Pushkar Y","Davis KM","Kosheleva I"],"additional_accession":[]},"is_claimable":false,"name":"Kinetic modeling of the X-ray-induced damage to a metalloprotein.","description":"It is well-known that biological samples undergo X-ray-induced degradation. One of the fastest occurring X-ray-induced processes involves redox modifications (reduction or oxidation) of redox-active cofactors in proteins. Here we analyze room-temperature data on the photoreduction of Mn ions in the oxygen-evolving complex (OEC) of photosystem II, one of the most radiation damage-sensitive proteins and a key constituent of natural photosynthesis in plants, green algae, and cyanobacteria. Time-resolved X-ray emission spectroscopy with wavelength-dispersive detection was used to collect data on the progression of X-ray-induced damage. A kinetic model was developed to fit experimental results, and the rate constant for the reduction of OEC Mn(III) and Mn(IV) ions by solvated electrons was dete","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Aug","modification":"2025-04-03T23:01:49.253Z","creation":"2019-03-27T01:20:19Z"},"accession":"S-EPMC3897202","cross_references":{"pubmed":["23815809"],"doi":["10.1021/jp403654n"]}}