{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Ingham AB"],"pubmed_abstract":["<h4>Background</h4>Muscle development and remodelling, mitochondrial physiology and inflammation are thought to be inter-related and to have implications for metabolism in both health and disease. However, our understanding of their molecular control is incomplete.<h4>Results</h4>In this study we have confirmed that the ring finger 14 protein (RNF14), a poorly understood transcriptional regulator, influences the expression of both mitochondrial and immune-related genes. The prediction was based on a combination of network connectivity and differential connectivity in cattle (a non-model organism) and mice data sets, with a focus on skeletal muscle. They assigned similar probability to mammalian RNF14 playing a regulatory role in mitochondrial and immune gene expression. To try and resolve "],"journal":["BMC systems biology"],"pagination":["10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3906743"],"repository":["biostudies-literature"],"pubmed_title":["RNF14 is a regulator of mitochondrial and immune function in muscle."],"pmcid":["PMC3906743"],"pubmed_authors":["Menzies M","Reverter A","Hudson NJ","Seymour R","Wijffels G","Osborne SA","Kongsuwan K","Jeanes A","Ingham AB","Chen W","Dalrymple BP","Briscoe S"],"additional_accession":[]},"is_claimable":false,"name":"RNF14 is a regulator of mitochondrial and immune function in muscle.","description":"<h4>Background</h4>Muscle development and remodelling, mitochondrial physiology and inflammation are thought to be inter-related and to have implications for metabolism in both health and disease. However, our understanding of their molecular control is incomplete.<h4>Results</h4>In this study we have confirmed that the ring finger 14 protein (RNF14), a poorly understood transcriptional regulator, influences the expression of both mitochondrial and immune-related genes. The prediction was based on a combination of network connectivity and differential connectivity in cattle (a non-model organism) and mice data sets, with a focus on skeletal muscle. They assigned similar probability to mammalian RNF14 playing a regulatory role in mitochondrial and immune gene expression. To try and resolve ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jan","modification":"2026-05-04T04:59:51.434Z","creation":"2019-03-27T01:20:53Z"},"accession":"S-EPMC3906743","cross_references":{"pubmed":["24472305"],"doi":["10.1186/1752-0509-8-10"]}}