biostudies-literatureUnknown8Ingham AB<h4>Background</h4>Muscle development and remodelling, mitochondrial physiology and inflammation are thought to be inter-related and to have implications for metabolism in both health and disease. However, our understanding of their molecular control is incomplete.<h4>Results</h4>In this study we have confirmed that the ring finger 14 protein (RNF14), a poorly understood transcriptional regulator, influences the expression of both mitochondrial and immune-related genes. The prediction was based on a combination of network connectivity and differential connectivity in cattle (a non-model organism) and mice data sets, with a focus on skeletal muscle. They assigned similar probability to mammalian RNF14 playing a regulatory role in mitochondrial and immune gene expression. To try and resolve BMC systems biology10https://www.ebi.ac.uk/biostudies/studies/S-EPMC3906743biostudies-literatureRNF14 is a regulator of mitochondrial and immune function in muscle.PMC3906743Menzies MReverter AHudson NJSeymour RWijffels GOsborne SAKongsuwan KJeanes AIngham ABChen WDalrymple BPBriscoe SfalseRNF14 is a regulator of mitochondrial and immune function in muscle.<h4>Background</h4>Muscle development and remodelling, mitochondrial physiology and inflammation are thought to be inter-related and to have implications for metabolism in both health and disease. However, our understanding of their molecular control is incomplete.<h4>Results</h4>In this study we have confirmed that the ring finger 14 protein (RNF14), a poorly understood transcriptional regulator, influences the expression of both mitochondrial and immune-related genes. The prediction was based on a combination of network connectivity and differential connectivity in cattle (a non-model organism) and mice data sets, with a focus on skeletal muscle. They assigned similar probability to mammalian RNF14 playing a regulatory role in mitochondrial and immune gene expression. To try and resolve 2014-01-01T00:00:00Z2014 Jan2026-05-04T04:59:51.434Z2019-03-27T01:20:53ZS-EPMC39067432447230510.1186/1752-0509-8-10