{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qiu W"],"funding":["National Cancer Institute","NCI NIH HHS"],"pagination":["810487"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3910486"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2014"],"pubmed_abstract":["Salivary duct carcinoma (SDC) is an aggressive malignant tumor with a high mortality, which resembles high-grade breast ductal carcinoma in morphology. The parotid gland is the most common location. Its molecular genetic characteristics remain largely unknown. We have previously reported high incidence of PIK3CA somatic mutations in head and neck squamous cell carcinoma, particularly in pharyngeal cancers. Here we examined the PIK3CA gene expression status and hotspot mutations in six cases of SDC by immunohistochemistry and genomic DNA sequencing. Immunohistochemistry showed that PIK3CA expression was elevated in all six patients with SDC. By DNA sequencing, two hotspot mutations of the PIK3CA gene, E545K (exon 9) and H1047R (exon 20), were identified in two of the six cases. Our results "],"journal":["BioMed research international"],"pubmed_title":["Oncogenic PIK3CA mutation and dysregulation in human salivary duct carcinoma."],"pmcid":["PMC3910486"],"funding_grant_id":["NCI R01 CA109525","R01 CA109525"],"pubmed_authors":["Caruana SM","Qiu W","Turk AT","Su GH","Tong GX","Close LG"],"additional_accession":[]},"is_claimable":false,"name":"Oncogenic PIK3CA mutation and dysregulation in human salivary duct carcinoma.","description":"Salivary duct carcinoma (SDC) is an aggressive malignant tumor with a high mortality, which resembles high-grade breast ductal carcinoma in morphology. The parotid gland is the most common location. Its molecular genetic characteristics remain largely unknown. We have previously reported high incidence of PIK3CA somatic mutations in head and neck squamous cell carcinoma, particularly in pharyngeal cancers. Here we examined the PIK3CA gene expression status and hotspot mutations in six cases of SDC by immunohistochemistry and genomic DNA sequencing. Immunohistochemistry showed that PIK3CA expression was elevated in all six patients with SDC. By DNA sequencing, two hotspot mutations of the PIK3CA gene, E545K (exon 9) and H1047R (exon 20), were identified in two of the six cases. Our results ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-05-18T11:16:34.909Z","creation":"2025-05-18T11:16:34.909Z"},"accession":"S-EPMC3910486","cross_references":{"pubmed":["24511546"],"doi":["10.1155/2014/810487"]}}