{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Merlo DF"],"funding":["National Institute for Health Research (NIHR)"],"pagination":["193-200"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3914866"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(2)"],"pubmed_abstract":["<h4>Background</h4>Leukemia incidence has increased in recent decades among European children, suggesting that early-life environmental exposures play an important role in disease development.<h4>Objectives</h4>We investigated the hypothesis that childhood susceptibility may increase as a result of in utero exposure to carcinogens and hormonally acting factors. Using cord blood samples from the NewGeneris cohort, we examined associations between a range of biomarkers of carcinogen exposure and hormonally acting factors with micronuclei (MN) frequency as a proxy measure of cancer risk. Associations with gene expression and genotype were also explored.<h4>Methods</h4>DNA and protein adducts, gene expression profiles, circulating hormonally acting factors, and GWAS (genome-wide association st"],"journal":["Environmental health perspectives"],"pubmed_title":["Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort."],"pmcid":["PMC3914866"],"funding_grant_id":["RP-PG-0407-10044"],"pubmed_authors":["Agramunt S","Brady NJ","NewGeneris Consortium","Chatzi L","Fthenou E","Besselink H","Hemminki K","Stagi E","Wright J","Singh R","Gallo F","Vande Loock K","Godschalk RW","Kleinjans JC","Segerback D","Nomark E","Schoket B","Sunyer J","Tornqvist M","Chen B","Nielsen JK","van Schooten FJ","Fontana V","Forsti A","Mijal R","Anna L","Fleming S","von Stedingk H","Gmuender H","Nygaard UC","van Delft JH","Lukacs V","Knudsen LE","Rydberg P","Georgiadis P","Kyrtopoulos SA","Decordier I","Botsivali M","Marcos R","Hardie LJ","Kogevinas M","Kovacs K","Pedersen M","Ceppi M","Lovik M","Kirsch-Volders M","Hochstenbach K","Granum B","Merlo DF","Anderson D","Farmer PB","van Loveren H"],"additional_accession":[]},"is_claimable":false,"name":"Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort.","description":"<h4>Background</h4>Leukemia incidence has increased in recent decades among European children, suggesting that early-life environmental exposures play an important role in disease development.<h4>Objectives</h4>We investigated the hypothesis that childhood susceptibility may increase as a result of in utero exposure to carcinogens and hormonally acting factors. Using cord blood samples from the NewGeneris cohort, we examined associations between a range of biomarkers of carcinogen exposure and hormonally acting factors with micronuclei (MN) frequency as a proxy measure of cancer risk. Associations with gene expression and genotype were also explored.<h4>Methods</h4>DNA and protein adducts, gene expression profiles, circulating hormonally acting factors, and GWAS (genome-wide association st","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Feb","modification":"2026-04-16T09:04:07.684Z","creation":"2026-04-07T14:07:24.57Z"},"accession":"S-EPMC3914866","cross_references":{"pubmed":["24252472"],"doi":["10.1289/ehp.1206324"]}}